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American Journal of Clinical Nutrition, Vol 53, 90-94, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of beta-carotene on lymphocyte subpopulations in elderly humans: evidence for a dose-response relationship [published erratum appears in Am J Clin Nutr 1991 Apr;53(4):988]

RR Watson, RH Prabhala, PM Plezia and DS Alberts
Department of Family and Community Medicine, College of Medicine, University of Arizona, Tucson 85724.

The effects of various doses (0, 15, 30, 45, and 60 mg/d) of supplementary beta-carotene were evaluated. The percentage of lymphoid cells with surface markers for T-helper and natural killer (NK) cells and cells with interleukin 2 (IL-2) and transferrin receptors were significantly and substantially increased in peripheral blood mononuclear cells collected from older human adult volunteers after supplementation with greater than or equal to 30 mg beta-carotene/d for 2 mo. The increase in the percentage of cells with markers of NK cells and in expression of IL-2 receptors was dose dependent. The plasma concentrations of beta-carotene were also elevated significantly; however, there was no increase in the amount of retinol present in plasma. This indicated that immunomodulation induced by beta-carotene may be due to the carotenoid rather than to an increased amount, and hence actions, of vitamin A. These results support the role of immunostimulation as a potential mechanism of action of beta-carotene with cancer-prevention potential.


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Copyright © 1991 by The American Society for Nutrition