| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 53, 403-412, Copyright © 1991 by The American Society for Clinical Nutrition, Inc
REVIEW ARTICLES |
AS Prasad
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI.
The importance of zinc for human health was first documented in 1963. During the past 25 y, deficiency of zinc in humans due to nutritional factors and several disease states has now been recognized. The high phytate content of cereal proteins is known to decrease the availability of zinc, thus the prevalence of zinc deficiency is likely to be high in a population consuming large quantities of cereal proteins. Alcoholism, malabsorption, sickle cell anemia, chronic renal disease, and chronically debilitating diseases are now known to be predisposing factors for zinc deficiency. A spectrum of clinical manifestations ranging from mild to severe degree have now been recognized in human zinc-deficiency states. Zinc is required for many biological functions including DNA synthesis, cell division, and gene expression. It is required for the activity of many enzymes in biological systems. Recent studies indicate that zinc is needed for cell-mediated immunity.
This article has been cited by other articles:
|
|
 |
|
  R. Aggarwal, J. Sentz, and M. A. Miller Role of Zinc Administration in Prevention of Childhood Diarrhea and Respiratory Illnesses: A Meta-analysis Pediatrics, June 1, 2007; 119(6): 1120 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. MURILLO-FUENTES, R. ARTILLO, M. L. OJEDA, M. J. DELGADO, M. L. MURILLO, and O. CARRERAS EFFECTS OF PRENATAL OR POSTNATAL ETHANOL CONSUMPTION ON ZINC INTESTINAL ABSORPTION AND EXCRETION IN RATS Alcohol Alcohol., January 1, 2007; 42(1): 3 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. J Griffin, P. D Hicks, L. K Liang, and S. A Abrams Metabolic adaptations to low zinc intakes in premenarcheal girls Am. J. Clinical Nutrition, August 1, 2004; 80(2): 385 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zlotkin, P. Arthur, C. Schauer, K. Y. Antwi, G. Yeung, and A. Piekarz Home-Fortification with Iron and Zinc Sprinkles or Iron Sprinkles Alone Successfully Treats Anemia in Infants and Young Children J. Nutr., April 1, 2003; 133(4): 1075 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H Brown, J. M Peerson, J. Rivera, and L. H Allen Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials Am. J. Clinical Nutrition, June 1, 2002; 75(6): 1062 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Grahn, P. G. Paterson, K. T. Gottschall-Pass, and Z. Zhang Zinc and the Eye J. Am. Coll. Nutr., April 1, 2001; 20(2): 106 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. I. Oteiza, M. S. Clegg, and C. L. Keen Short-Term Zinc Deficiency Affects Nuclear Factor-{{kappa}}B Nuclear Binding Activity in Rat Testes J. Nutr., January 1, 2001; 131(1): 21 - 26. [Abstract] [Full Text]
|
|
|
|
|
|
R. J. Wood Assessment of Marginal Zinc Status in Humans J. Nutr., May 1, 2000; 130(5): 1350S - 1354. [Abstract] [Full Text]
|
|
|
|
|
|
E. Mocchegiani and M. Muzzioli Therapeutic Application of Zinc in Human Immunodeficiency Virus against Opportunistic Infections J. Nutr., May 1, 2000; 130(5): 1424S - 1431. [Abstract] [Full Text]
|
|
|
|
|
|
M. P. Sciaudone, S. Chattopadhyay, and H. C. Freake Chelation of Zinc Amplifies Induction of Growth Hormone mRNA Levels in Cultured Rat Pituitary Tumor Cells J. Nutr., January 1, 2000; 130(2): 158 - 163. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. A. Suhy, K. D. Simon, D. I. H. Linzer, and T. V. O'Halloran Metallothionein Is Part of a Zinc-scavenging Mechanism for Cell Survival under Conditions of Extreme Zinc Deprivation J. Biol. Chem., April 2, 1999; 274(14): 9183 - 9192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Sorensen, I. A. Bergdahl, N. H. I. Hjollund, J. P. E. Bonde, M. Stoltenberg, and E. Ernst Zinc, magnesium and calcium in human seminal fluid: relations to other semen parameters and fertility Mol. Hum. Reprod., April 1, 1999; 5(4): 331 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Mantzoros, A. S. Prasad, F. W.J. Beck, S. Grabowski, J. Kaplan, C. Adair, and G. J. Brewer Zinc May Regulate Serum Leptin Concentrations in Humans J. Am. Coll. Nutr., June 1, 1998; 17(3): 270 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Martinez, G. Ros, M.J. Periago, G. Lopez, J. Ortuno, and F. Rincon El acido fitico en la alimentacion humana/Phytic acid in human nutrition Food Science and Technology International, January 1, 1996; 2(4): 201 - 209. [PDF]
|
|
|
|
 |
|
 S. Sazawal, R. E. Black, M. K. Bhan, N. Bhandari, A. Sinha, and S. Jalla Zinc Supplementation in Young Children with Acute Diarrhea in India N. Engl. J. Med., September 28, 1995; 333(13): 839 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Goldenberg, T. Tamura, Y. Neggers, R. L. Copper, K. E. Johnston, M. B. DuBard, and J. C. Hauth The Effect of Zinc Supplementation on Pregnancy Outcome JAMA, August 9, 1995; 274(6): 463 - 468. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
