American Journal of Clinical Nutrition, Vol 53, 491-498, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Dietary saturated fatty acids (12:0, 14:0, 16:0) differ in their impact on plasma cholesterol and lipoproteins in nonhuman primates

KC Hayes, A Pronczuk, S Lindsey and D Diersen-Schade
Foster Biomedical Research Laboratory, Brandeis University, Waltham, MA 02254.

Three species of monkey (rhesus, cebus, and squirrel) were rotated through five purified diets containing 31% energy as various fat blends (P:S between 0.1 and 1.0) for 12-wk periods to compare the impact of specific dietary fatty acids on plasma lipids and lipoproteins. As 12:0 + 14:0 was replaced by 16:0, a significant decrease occurred in total and LDL cholesterol, whereas slight increases in total cholesterol and the LDL-HDL ratio occurred when 16:0 replaced 18:2. Hegsted and Keys regression equations provided a good fit for the observed data, but the predicted total cholesterol response was perfect (r = 0.995) for both equations when 16:0 was considered neutral. Thus, under these conditions 16:0 was less cholesterolemic than 12:0 + 14:0 and only slightly cholesterolemic compared with 18:2.

This article has been cited by other articles:

				S. Vega-Lopez, L. M Ausman, S. M Jalbert, A. T Erkkila, and A. H Lichtenstein Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects Am. J. Clinical Nutrition, July 1, 2006; 84(1): 54 - 62. [Abstract] [Full Text] [PDF]

				S. V. Gupta, N. Yamada, T. V. Fungwe, and P. Khosla Replacing 40% of Dietary Animal Fat with Vegetable Oil Is Associated with Lower HDL Cholesterol and Higher Cholesterol Ester Transfer Protein in Cynomolgus Monkeys Fed Sufficient Linoleic Acid J. Nutr., August 1, 2003; 133(8): 2600 - 2606. [Abstract] [Full Text] [PDF]

				S. V. Gupta and P. Khosla Palmitic and Stearic Acids Similarly Affect Plasma Lipoprotein Metabolism in Cynomolgus Monkeys Fed Diets with Adequate Levels of Linoleic Acid J. Nutr., August 1, 2001; 131(8): 2115 - 2120. [Abstract] [Full Text] [PDF]

				N. Dashti, Q. Feng, and F. A. Franklin Long-term effects of cis and trans monounsaturated (18:1) and saturated (16:0) fatty acids on the synthesis and secretion of apolipoprotein A-I- and apolipoprotein B-containing lipoproteins in HepG2 cells J. Lipid Res., December 1, 2000; 41(12): 1980 - 1990. [Abstract] [Full Text]

				S. V. Gupta and P. Khosla Pork Fat and Chicken Fat Similarly Affect Plasma Lipoprotein Metabolism in Cynomolgus Monkeys Fed Diets with Adequate Levels of Linoleic Acid J. Nutr., May 1, 2000; 130(5): 1217 - 1224. [Abstract] [Full Text]

				C. T Phan, B.-C. Mortimer, I. J Martins, and T. G Redgrave Plasma clearance of chylomicrons from butterfat is not dependent on saturation: studies with butterfat fractions and other fats containing triacylglycerols with low or high melting points Am. J. Clinical Nutrition, June 1, 1999; 69(6): 1151 - 1161. [Abstract] [Full Text] [PDF]

				C. A. Hassel, E. A. Mensing, and D. D. Gallaher Dietary Stearic Acid Reduces Plasma and Hepatic Cholesterol Concentrations without Increasing Bile Acid Excretion in Cholesterol-Fed Hamsters J. Nutr., June 1, 1997; 127(6): 1148 - 1155. [Abstract] [Full Text]

				J. Zhang, W. Ping, W. Chunrong, C. X. Shou, and G. Keyou Nonhypercholesterolemic Effects of a Palm Oil Diet in Chinese Adults J. Nutr., March 1, 1997; 127(3): 509 - 509. [Abstract] [Full Text]

				P. Khosla, T. Hajri, A. Pronczuk, and K. C. Hayes Decreasing Dietary Lauric and Myristic Acids Improves Plasma Lipids More Favorably Than Decreasing Dietary Palmitic Acid in Rhesus Monkeys Fed AHA Step 1 Type Diets J. Nutr., March 1, 1997; 127(3): 525 - 525. [Abstract] [Full Text]

				P. Khosla, T. Hajri, A. Pronczuk, and K. C. Hayes Replacing Dietary Palmitic Acid with Elaidic Acid (t-C18:1Delta 9) Depresses HDL and Increases CETP Activity in Cebus Monkeys J. Nutr., March 1, 1997; 127(3): 531 - 531. [Abstract] [Full Text]