AJCN Tufts Nutrition Symposium, Boston Sept 24-26
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nozaki, S.
Right arrow Articles by Grundy, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nozaki, S.
Right arrow Articles by Grundy, S. M.
Agricola
Right arrow Articles by Nozaki, S.
Right arrow Articles by Grundy, S. M.

American Journal of Clinical Nutrition, Vol 53, 638-642, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Postheparin lipolytic activity and plasma lipoprotein response to omega- 3 polyunsaturated fatty acids in patients with primary hypertriglyceridemia

S Nozaki, A Garg, GL Vega and SM Grundy
Veterans Administration Medical Center, Dallas, TX.

The hypotriglyceridemic action of omega-3 (n-3) fatty acids is attributed primarily to reduction in hepatic triglyceride synthesis and reduced secretion of very-low-density lipoproteins (VLDLs). However, increased catabolism of triglyceride-rich lipoproteins was reported and could be due to increased availability of peripheral lipoprotein lipase (LPL) or hepatic lipase (HL). In this study plasma lipoproteins and postheparin activities of LPL and HL were determined in 12 patients with primary hypertriglyceridemia before and during isocaloric substitution of omega-3 fatty acids (10 g/d) for 4 wk. Omega-3 polyunsaturates resulted in 53% and 61% reductions in plasma triglyceride and VLDL-cholesterol concentrations, respectively (P less than 0.0001). However, low-density-lipoprotein (LDL)-cholesterol concentrations increased by 26% (P less than 0.001). Activities of postheparin LPL and HL essentially remained the same. Thus, in patients with primary hypertriglyceridemia, reduction in plasma triglyceride concentrations and increase in LDL-cholesterol concentrations mediated by omega-3 polyunsaturates seem to occur without an increase in LPL or HL activities.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
T. A Jacobson
Role of n-3 fatty acids in the treatment of hypertriglyceridemia and cardiovascular disease
Am. J. Clinical Nutrition, June 1, 2008; 87(6): 1981S - 1990S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
Y. Park, P. G Jones, and W. S Harris
Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and effects of eicosapentaenoic and docosahexaenoic acids
Am. J. Clinical Nutrition, July 1, 2004; 80(1): 45 - 50.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
L. F. Larsen, A. K. Olsen, A. K. Hansen, K. Bukhave, and P. Marckmann
Feeding Minipigs Fish Oil for Four Weeks Lowers Postprandial Triacylglycerolemia
J. Nutr., July 1, 2003; 133(7): 2273 - 2276.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
Y. Park and W. S. Harris
Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
J. Lipid Res., March 1, 2003; 44(3): 455 - 463.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
S. Khan, A.-M. Minihane, P. J. Talmud, J. W. Wright, M. C. Murphy, C. M. Williams, and B. A. Griffin
Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype
J. Lipid Res., June 1, 2002; 43(6): 979 - 985.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
C. Vasandani, A. I. Kafrouni, A. Caronna, Y. Bashmakov, M. Gotthardt, J. D. Horton, and D. K. Spady
Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice
J. Lipid Res., May 1, 2002; 43(5): 772 - 784.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
G. Asset, E. Bauge, J. C. Fruchart, and J. Dallongeville
Lack of Triglyceride-Lowering Properties of Fish Oil in Apolipoprotein E-Deficient Mice
Arterioscler. Thromb. Vasc. Biol., March 1, 2001; 21(3): 401 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. M. Minihane, S. Khan, E. C. Leigh-Firbank, P. Talmud, J. W. Wright, M. C. Murphy, B. A. Griffin, and C. M. Williams
ApoE Polymorphism and Fish Oil Supplementation in Subjects With an Atherogenic Lipoprotein Phenotype
Arterioscler. Thromb. Vasc. Biol., August 1, 2000; 20(8): 1990 - 1997.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. R. Thomas, B. A. Fischer, W. B. Kist, K. E. Horner, and R. H. Cox
Effects of exercise and n-3 fatty acids on postprandial lipemia
J Appl Physiol, June 1, 2000; 88(6): 2199 - 2204.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
B. Lacaille, P. Julien, Y. Deshaies, C. Lavigne, L.-D Brun, and H. Jacques
Responses of Plasma Lipoproteins and Sex Hormones to the Consumption of Lean Fish Incorporated in a Prudent-Type Diet in Normolipidemic Men
J. Am. Coll. Nutr., June 1, 2000; 19(6): 745 - 753.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
W. R. Fisher, L. A. Zech, and P. W. Stacpoole
Apolipoprotein B metabolism in hypertriglyceridemic diabetic patients administered either a fish oil- or vegetable oil-enriched diet
J. Lipid Res., February 1, 1998; 39(2): 388 - 401.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by The American Society for Nutrition