American Journal of Clinical Nutrition, Vol 53, 660-664, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Lack of effect of linoleic acid on the high-density-lipoprotein- cholesterol fraction of plasma lipoproteins

JM Iacono and RM Dougherty
US Department of Agriculture, Western Human Nutrition Research Center, Presidio of San Francisco, CA 94129.

Low-fat, natural diets were fed to 11 middle-aged, healthy male subjects for two 40-d periods to determine effects on plasma lipoproteins. The diets were designed to maintain saturated and monounsaturated fatty acids at 10 en% and linoleic acid (LA) at 3.8 and 10.8 en%. When compared with baseline concentrations, total cholesterol decreased 10% at the end of the lower LA diet and 15% at the end of the higher LA diet. Low-density-lipoprotein cholesterol (LDL-C) decreased 18% and 22%, respectively, during the same periods. Plasma high-density- lipoprotein cholesterol (HDL-C) at the end of each dietary period was not significantly different but the midpoint values were lower by 12.5% on the lower LA diet and 7.3% on the higher LA diet. Apolipoprotein B decreased 27% at the end of the lower LA diet and 37% at the end of the higher LA diet whereas apolipoprotein A-I increased 18% and 24%, respectively. HDL-C was not reduced by dietary LA over a 6-wk period.

This article has been cited by other articles:

				R. P Mensink, P. L Zock, A. D. Kester, and M. B Katan Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1146 - 1155. [Abstract] [Full Text] [PDF]

				E. B. Feldman The Scientific Evidence for a Beneficial Health Relationship Between Walnuts and Coronary Heart Disease J. Nutr., May 1, 2002; 132(5): 1062S - 1101. [Abstract] [Full Text] [PDF]

				J. Eritsland Safety considerations of polyunsaturated fatty acids Am. J. Clinical Nutrition, January 1, 2000; 71(1): 197S - 201S. [Abstract] [Full Text] [PDF]