AJCN Tufts Nutrition Symposium, Boston Sept 24-26
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stegink, L. D.
Right arrow Articles by Ziegler, E. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stegink, L. D.
Right arrow Articles by Ziegler, E. E.
Agricola
Right arrow Articles by Stegink, L. D.
Right arrow Articles by Ziegler, E. E.

American Journal of Clinical Nutrition, Vol 53, 670-675, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Plasma amino acid concentrations and amino acid ratios in normal adults and adults heterozygous for phenylketonuria ingesting a hamburger and milk shake meal

LD Stegink, LJ Filer Jr, MC Brummel, GL Baker, WL Krause, EF Bell and EE Ziegler
Department of Pediatrics, University of Iowa College of Medicine, Iowa City 52242.

Plasma amino acid concentrations were measured and selected amino acid ratios were calculated in 12 normal adults and 12 adults heterozygous for phenylketonuria (PKU) ingesting a hamburger and milk shake meal providing 1 g protein/kg body wt. Plasma concentrations of all amino acids increased significantly over baseline after meal ingestion in both groups, reaching the highest mean values 3-5 h after meal ingestion. Plasma phenylalanine concentrations were significantly higher in heterozygous than in normal subjects both before and at all times after meal ingestion. The absolute increase in plasma phenylalanine concentration over baseline and the area under the plasma phenylalanine concentration-time curve were approximately twice as large in heterozygous as in normal subjects. However, the molar ratio of the plasma phenylalanine concentration to the sum of the plasma concentrations of the other large neutral amino acids did not increase significantly over baseline, but rather decreased.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
P. B Acosta, K. Matalon, L. Castiglioni, F. J Rohr, E. Wenz, V. Austin, and C. Azen
Intake of major nutrients by women in the Maternal Phenylketonuria (MPKU) Study and effects on plasma phenylalanine concentrations
Am. J. Clinical Nutrition, April 1, 2001; 73(4): 792 - 796.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Kaufman
A model of human phenylalanine metabolism in normal subjects and in phenylketonuric patients
PNAS, March 16, 1999; 96(6): 3160 - 3164.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. L. Wolraich, S. D. Lindgren, P. J. Stumbo, L. D. Stegink, M. I. Appelbaum, and M. C. Kiritsy
Effects of Diets High in Sucrose or Aspartame on The Behavior and Cognitive Performance of Children
N. Engl. J. Med., February 3, 1994; 330(5): 301 - 307.
[Abstract] [Full Text]

Home page
 CLIN PEDIATRHome page
S. A. Mackey and C. M. Berlin JR
Effect of Dietary Aspartame on Plasma Concentrations of Phenylalanine and Tyrosine in Normal and Homozygous Phenylketonuric Patients
Clinical Pediatrics, July 1, 1992; 31(7): 394 - 399.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by The American Society for Nutrition