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American Journal of Clinical Nutrition, Vol 53, 847-853, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats

MY Cortez, CE Torgan, JT Brozinick Jr, RH Miller and JL Ivy
Department of Kinesiology, University of Texas, Austin, TX 78712.

Female obese Zucker rats (aged 6 wk) were randomly assigned to one of two control or one of three experimental-diet groups. Experimental diets contained 6% pyruvate (Pyr). 6% dihydroxyacetone (Dha), or 3% each pyruvate and dihydroxyacetone (Pyr-Dha). Control-group 1 was fed a normal diet ad libitum and control-group 2 was pair fed according to the experimental group with the lowest consumption. After 5 wk the rats receiving Pyr (357.5 +/- 12.7 g) were significantly lighter than pair- fed (385.9 +/- 4.9 g) and ad libitum-fed (404.3 +/- 10.1) controls. Resting oxygen consumption (mL.min-1.kg0.65) was significantly higher in Pyr-fed rats than in pair-fed controls and food-conversion efficiency was significantly decreased. Rats fed Pyr had a lower resting respiratory-exchange ratio than did ad libitum- and pair-fed controls (0.81 +/- 0.01 vs 0.88 +/- 0.01 and 0.87 +/- 0.01, respectively). Results suggest that pyruvate consumption reduced the weight gain and food-conversion efficiency of obese Zucker rats, in part by increasing resting metabolic rate and fatty acid oxidation.


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Copyright © 1991 by The American Society for Nutrition