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American Journal of Clinical Nutrition, Vol 53, 865-871, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of a tricyclic antidepressant and opiate antagonist on binge- eating behavior in normoweight bulimic and obese, binge-eating subjects

SA Alger, MD Schwalberg, JM Bigaouette, AV Michalek and LJ Howard
Division of Clinical Nutrition, Albany Medical College, NY 12208.

A subset of the obese population (25-30%) has been reported to engage in binge eating at least twice weekly (bingers) and to exhibit personality traits and food attitudes similar to those of normoweight bulimic women (bulimics). Tricyclic antidepressants and opiate antagonists effectively suppress binge eating in normoweight bulimics. This 8-wk placebo-controlled, double-blind trial investigated the effect of naltrexone and imipramine on 33 obese bingers and 22 bulimics. Naltrexone (100-150 mg/d) produced a significant reduction in binge duration in bulimics (36 +/- 16%, median +/- SIQR; P = 0.02) whereas imipramine significantly reduced binge duration in obese bingers (88 +/- 31%; P = 0.02). A strong placebo effect was observed in obese bingers and, although a reduction in binge frequency occurred with both naltrexone and imipramine, it was not significantly different from the effect in placebo control subjects. We conclude that naltrexone and imipramine may be useful agents in the treatment of binge eating.


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References
PsychiatryOnline CME, May 1, 2007; 2007(1): 2 - 2.
[Full Text]

Home page
 Arch Gen PsychiatryHome page
J. C. Appolinario, J. Bacaltchuk, R. Sichieri, A. M. Claudino, A. Godoy-Matos, C. Morgan, M. T. Zanella, and W. Coutinho
A Randomized, Double-blind, Placebo-Controlled Study of Sibutramine in the Treatment of Binge-Eating Disorder
Arch Gen Psychiatry, November 1, 2003; 60(11): 1109 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
D. E. Wilfley, R. R. Welch, R. I. Stein, E. B. Spurrell, L. R. Cohen, B. E. Saelens, J. Z. Dounchis, M. A. Frank, C. V. Wiseman, and G. E. Matt
A Randomized Comparison of Group Cognitive-Behavioral Therapy and Group Interpersonal Psychotherapy for the Treatment of Overweight Individuals With Binge-Eating Disorder
Arch Gen Psychiatry, August 1, 2002; 59(8): 713 - 721.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
G. A. Bray and F. L. Greenway
Current and Potential Drugs for Treatment of Obesity
Endocr. Rev., December 1, 1999; 20(6): 805 - 875.
[Abstract] [Full Text]

Home page
 Am. J. PsychiatryHome page
J. I. Hudson, S. L. McElroy, N. C. Raymond, S. Crow, P. E. Keck Jr., W. P. Carter, J. E. Mitchell, S. M. Strakowski, H. G. Pope Jr., B. S. Coleman, et al.
Fluvoxamine in the Treatment of Binge-Eating Disorder: A Multicenter Placebo-Controlled, Double-Blind Trial
Am J Psychiatry, December 1, 1998; 155(12): 1756 - 1762.
[Abstract] [Full Text]


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