American Journal of Clinical Nutrition, Vol 54, 118-122, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

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n-3 polyunsaturated fatty acids raise low-density lipoproteins, high- density lipoprotein 2, and plasminogen-activator inhibitor in healthy young men

F Fumeron, L Brigant, V Ollivier, D de Prost, F Driss, P Darcet, JM Bard, HJ Parra, JC Fruchart and M Apfelbaum
INSERM U 286, Faculte X Bichat, Paris, France.

The effects of a moderate supplementation in n-3 polyunsaturated fatty acids (PUFAs) were investigated in 36 young healthy adult males. Factors investigated were lipoprotein (including HDL subfractions and apolipoproteins) and hemostasis indexes, assessed by platelet aggregation and plasminogen-activator-inhibitor (PAI) activity. Fat- controlled diets were prescribed, one with and one without a fish-oil supplement (control diet), successively during 3 wk in random order. Total calorie, fat, and cholesterol intakes were similar in the two diets. Triglycerides in serum and very-low-density lipoproteins were lower and high-density-lipoprotein 2 cholesterol was higher with the n- 3 PUFA-supplemented diet. These effects as well as a significant decrease in platelet aggregation can be considered beneficial in terms of cardiovascular risk. However, significant increases in low-density- lipoprotein cholesterol and PAI activity occurred and were correlated. This latter effect could be detrimental.

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