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American Journal of Clinical Nutrition, Vol 54, 188S-192S, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Application of intermediate biomarkers to studies of cancer prevention in the gastrointestinal tract: introduction and perspective

M Lipkin
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY.

In this article, abnormalities in the proliferation and differentiation of gastrointestinal cells are described in diseases that increase predisposition to gastrointestinal cancer. Recent findings related to the effects of calcium on gastrointestinal cell proliferation, differentiation, and tumor occurrence in rodent models and in human subjects are summarized.


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Copyright © 1991 by The American Society for Nutrition