American Journal of Clinical Nutrition, Vol 54, 351-358, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids

JS Kwon, JT Snook, GM Wardlaw and DH Hwang
Department of Human Nutrition, Ohio State University, Columbus.

Platelet function and fatty acid composition were investigated in 30 healthy male subjects who ate a controlled-saturated-fatty-acid (baseline) diet for 3 wk and then consumed either safflower oil or canola oil as a major fat source for 8 wk. Fatty acid composition of platelet phospholipids reflected changes in dietary fatty acid composition. Compared with baseline a 35% decrease (P less than 0.05) in arachidonic acid was observed in platelet phospholipids of the canola-oil diet group while long chain n-3 fatty acids rose 7-26% (P greater than 0.05). Compared with baseline both unsaturated-fatty-acid diets reduced platelet aggregation at 3 wk of oil-based diet feeding (P less than 0.01) whereas only canola oil influenced platelet function (lowered ATP secretion) at 8 wk (P less than 0.01). No significant difference was observed in thromboxane B2 concentrations between oil- treatment groups at 8 wk. Both oil-based diets had short-term beneficial effects on platelet function but the effect of canola oil persisted longer.

This article has been cited by other articles:

				Q. Sun, J. Ma, H. Campos, and F. B Hu Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart disease Am. J. Clinical Nutrition, October 1, 2007; 86(4): 929 - 937. [Abstract] [Full Text] [PDF]

				C. M. Skeaff, L. Hodson, and J. E. McKenzie Dietary-Induced Changes in Fatty Acid Composition of Human Plasma, Platelet, and Erythrocyte Lipids Follow a Similar Time Course J. Nutr., March 1, 2006; 136(3): 565 - 569. [Abstract] [Full Text] [PDF]

				M. A.M.A. Thijssen, G. Hornstra, and R. P. Mensink Stearic, Oleic, and Linoleic Acids Have Comparable Effects on Markers of Thrombotic Tendency in Healthy Human Subjects J. Nutr., December 1, 2005; 135(12): 2805 - 2811. [Abstract] [Full Text] [PDF]

				J. Westerbacka, K. Lammi, A.-M. Hakkinen, A. Rissanen, I. Salminen, A. Aro, and H. Yki-Jarvinen Dietary Fat Content Modifies Liver Fat in Overweight Nondiabetic Subjects J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2804 - 2809. [Abstract] [Full Text] [PDF]

				S. C. Park, Y. Liu-Stratton, L. C. Medeiros, S. A. Mccune, and M. J. Radin Effect of Male Sex and Obesity on Platelet Arachidonic Acid in Spontaneous Hypertensive Heart Failure Rats Experimental Biology and Medicine, July 1, 2004; 229(7): 657 - 664. [Abstract] [Full Text] [PDF]

				R. P Mensink, P. L Zock, A. D. Kester, and M. B Katan Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1146 - 1155. [Abstract] [Full Text] [PDF]

				S. K. Raatz, D. Bibus, W. Thomas, and P. Kris-Etherton Total Fat Intake Modifies Plasma Fatty Acid Composition in Humans J. Nutr., February 1, 2001; 131(2): 231 - 234. [Abstract] [Full Text]

				S. M. Innis and R. A. Dyer Dietary Canola Oil Alters Hematological Indices and Blood Lipids in Neonatal Piglets Fed Formula J. Nutr., July 1, 1999; 129(7): 1261 - 1268. [Abstract] [Full Text]

				D. Li, A. Sinclair, A. Wilson, S. Nakkote, F. Kelly, L. Abedin, N. Mann, and A. Turner Effect of dietary {alpha}-linolenic acid on thrombotic risk factors in vegetarian men Am. J. Clinical Nutrition, May 1, 1999; 69(5): 872 - 882. [Abstract] [Full Text] [PDF]

				C. D. Gardner and H. C. Kraemer Monounsaturated Versus Polyunsaturated Dietary Fat and Serum Lipids : A Meta-analysis Arterioscler Thromb Vasc Biol, November 1, 1995; 15(11): 1917 - 1927. [Abstract] [Full Text]