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American Journal of Clinical Nutrition, Vol 54, 674-677, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Peroxisomes and the fatty liver of malnutrition: an hypothesis

JF Doherty, MH Golden and SE Brooks
Tropical Metabolism Research Unit, University of the West Indies, Kingston, Jamaica.

Peroxisomes play a role in hepatic beta-oxidation of fat, a process that results in the production of hydrogen peroxide. The fatty infiltration of the liver that occurs in severely malnourished children remains unexplained. We observed an almost total absence of peroxisomes in the hepatocytes of these children. We suggest that lack of available peroxisomes could contribute to the development of fatty liver.


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Copyright © 1991 by The American Society for Nutrition