American Journal of Clinical Nutrition, Vol 54, 903-908, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Efficacy of calcium glycerophosphate vs conventional mineral salts for total parenteral nutrition in low-birth-weight infants: a randomized clinical trial

RM Hanning, SA Atkinson and RK Whyte
Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

To test the efficacy of calcium glycerophosphate (CaGlyP) vs the conventional mineral salts, calcium gluconate plus KH2PO4 + K2HPO4 (CaGluc + P), in promoting mineral retention, 72-h mineral balance, biochemical status, net acid excretion, and growth were assessed in 16 low-birth-weight infants receiving total parenteral nutrition (TPN) containing approximately 1.5 mmol Ca and P.kg-1.d-1 for 5 d. Net retentions of calcium (1.2 +/- 0.2 vs 1.0 +/- 0.2 mmol.kg-1.d-1, means +/- SD) and phosphorus (1.1 +/- 0.3 vs 0.8 +/- 0.3 mmol.kg-1.d-1) from CaGluc + P vs CaGlyP, respectively, were similar, as were retentions of magnesium and sodium, urinary pH, and net acid excretion. Plasma ionized calcium, inorganic phosphorus, alkaline phosphatase, and osteocalcin were normal and not different between groups. CaGlyP is as effective as CaGluc + P in promoting mineral retention and normal mineral homeostasis. However, at intakes of less than or equal to 1.5 mmol Ca and P.kg-1.d-1 from either mineral salt, retention represented only 60% and 45%, respectively, of the predicted intrauterine accretion for calcium and phosphorus. Larger intakes permitted by the more- soluble CaGlyP may be desirable for infants receiving TPN.

This article has been cited by other articles:

				M. Prinzivalli and S. Ceccarelli Sodium d-Fructose-1,6-Diphosphate vs. Sodium Monohydrogen Phosphate in Total Parenteral Nutrition: A Comparative In Vitro Assessment of Calcium/Phosphate Compatibility JPEN J Parenter Enteral Nutr, November 1, 1999; 23(6): 326 - 332. [Abstract] [PDF]

				J. F. Mouser and G. S. Sacks Vitamin D and Minerals: How Much for Preterm Infants During a Multivitamin Shortage? Nutr Clin Pract, April 1, 1999; 14(2): 51 - 57. [Abstract] [PDF]

				C. Berkelhammer, R. J. Wood, and M. D. Sitrin Inorganic Phosphorus Reduces Hypercalciuria During Total Parenteral Nutrition By Enhancing Renal Tubular Calcium Absorption JPEN J Parenter Enteral Nutr, May 1, 1998; 22(3): 142 - 146. [Abstract] [PDF]