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American Journal of Clinical Nutrition, Vol 54, 1153S-1156S, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

The role of ascorbate in the biosynthesis of neuroendocrine peptides

BA Eipper and RE Mains
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

The biosynthesis of all alpha-amidated peptides requires the participation of peptidylglycine alpha-amidating monooxygenase (PAM), a bifunctional enzyme dependent on molecular oxygen, ascorbate, and copper. In the AtT-20 corticotrope cell line, reduced concentrations of PAM and ascorbate can make alpha-amidation the rate-limiting step in the production of bioactive product peptide. Production of various peptides thought to play autocrine and paracrine roles may be affected by ascorbate availability.




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Copyright © 1991 by The American Society for Nutrition