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American Journal of Clinical Nutrition, Vol 54, 1173S-1178S, Copyright © 1991 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Cytochrome b561, ascorbic acid, and transmembrane electron transfer

PJ Fleming and UM Kent
Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007.

Cytochrome b561 is a transmembrane protein unique to neuroendocrine secretory vesicles. It acts as an electron channel and mediates equilibration of ascorbate-semidehydroascorbate inside the secretory vesicle with the ascorbate redox pair in the cytoplasm. The role for this function is to regenerate ascorbate inside the secretory vesicle for use by monooxygenases. Elucidation of the structure and mechanism of redox activity of cytochrome b561 may demonstrate paradigms for other ascorbate-utilizing enzymes as well as provide insights into long- range biological electron transfer.


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D. Su, J. M. May, M. J. Koury, and H. Asard
Human Erythrocyte Membranes Contain a Cytochrome b561 That May Be Involved in Extracellular Ascorbate Recycling
J. Biol. Chem., December 29, 2006; 281(52): 39852 - 39859.
[Abstract] [Full Text] [PDF]


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Copyright © 1991 by The American Society for Nutrition