AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, E. J.
Right arrow Articles by Russell, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, E. J.
Right arrow Articles by Russell, R. M.
Agricola
Right arrow Articles by Johnson, E. J.
Right arrow Articles by Russell, R. M.

American Journal of Clinical Nutrition, Vol 55, 857-864, Copyright © 1992 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Evaluation of vitamin A absorption by using oil-soluble and water- miscible vitamin A preparations in normal adults and in patients with gastrointestinal disease

EJ Johnson, SD Krasinski, LJ Howard, SA Alger, SK Dutta and RM Russell
USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111.

We evaluated vitamin A absorption in 50 healthy adults and 26 gastrointestinal-disease patients by measuring the postabsorptive response in plasma retinyl esters after oral doses of the vitamin. On 3 consecutive days, two physiologic-dose tests of 2000-2400 retinol equivalents (RE) and one pharmacologic-dose test (84,000 RE) were administered. The physiologic doses were given as an oil-soluble or a water-miscible preparation. In gastrointestinal-disease patients the physiologic-dose test was highly correlated with the pharmacologic-dose test for the oil-soluble preparation as determined by peak rise (r = 0.50, P less than 0.05) and area under the curve (r = 0.56, P less than 0.01), suggesting that the physiologic dose is valid for investigating vitamin A absorption. Intestinal-disease or resection patients absorbed preparations poorly. Pancreatic-disease patients absorbed the oil- soluble preparation poorly. Physiologic rather than pharmacologic doses of vitamin A can be used to study vitamin A absorption.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
A. M Myhre, M. H Carlsen, S. K Bohn, H. L Wold, P. Laake, and R. Blomhoff
Water-miscible, emulsified, and solid forms of retinol supplements are more toxic than oil-based preparations
Am. J. Clinical Nutrition, December 1, 2003; 78(6): 1152 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. Borel, B. Pasquier, M. Armand, V. Tyssandier, P. Grolier, M.-C. Alexandre-Gouabau, M. Andre, M. Senft, J. Peyrot, V. Jaussan, et al.
Processing of vitamin A and E in the human gastrointestinal tract
Am J Physiol Gastrointest Liver Physiol, January 1, 2001; 280(1): G95 - G103.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
C. B. Stephensen, L. M. Franchi, H. Hernandez, M. Campos, R. H. Gilman, and J. O. Alvarez
Adverse Effects of High-dose Vitamin A Supplements in Children Hospitalized With Pneumonia
Pediatrics, May 1, 1998; 101 (5): e3 - e3.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
G. C. Daher, D. A. Cooper, N. L. Zorich, D. King, K. A. Riccardi, and J. C. Peters
Olestra Ingestion and Retinyl Palmitate Absorption in Humans
J. Nutr., August 1, 1997; 127(8): 1686 - 1686.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by The American Society for Nutrition