AJCN EB Program 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Renaud, S. C.
Right arrow Articles by Elwood, P. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Renaud, S. C.
Right arrow Articles by Elwood, P. C.
Agricola
Right arrow Articles by Renaud, S. C.
Right arrow Articles by Elwood, P. C.

American Journal of Clinical Nutrition, Vol 55, 1012-1017, Copyright © 1992 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Alcohol and platelet aggregation: the Caerphilly Prospective Heart Disease Study

SC Renaud, AD Beswick, AM Fehily, DS Sharp and PC Elwood
INSERM Unit 63, Bron, France.

Intakes of alcohol and saturated fatty acids were determined through a dietary questionnaire from 1600 men (aged 49-66 y) in the Caerphilly Prospective Heart Disease Study. Platelet aggregation induced by thrombin adenosine disphosphate (ADP), and collagen was studied in subjects who had fasted and had not recently taken drugs affecting platelets. In subjects who drank alcohol, the odds ratio of a high response to aggregation was significantly reduced (primary ADP, P less than 0.05; secondary ADP, P less than 0.001; collagen, P less than 0.02). The significance was enhanced by adjusting for smoking and by including only the subjects with a high intake of saturated fatty acids or a low intake of polyunsaturated fatty acids. By contrast, the responsiveness to thrombin was slightly increased at all levels of alcohol consumption. We therefore suggest that part of the effects of alcohol on coronary heart disease may be mediated by a dose-dependent effect on certain platelet functions, modulated by the intake of dietary fat.


This article has been cited by other articles:


Home page
 J. Nutr.Home page
J. W. Erdman Jr., D. Balentine, L. Arab, G. Beecher, J. T. Dwyer, J. Folts, J. Harnly, P. Hollman, C. L. Keen, G. Mazza, et al.
Flavonoids and Heart Health: Proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC
J. Nutr., March 1, 2007; 137(3): 718S - 737S.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. Gazzieri, M. Trevisani, F. Tarantini, P. Bechi, G. Masotti, G. F. Gensini, S. Castellani, N. Marchionni, P. Geppetti, and S. Harrison
Ethanol dilates coronary arteries and increases coronary flow via transient receptor potential vanilloid 1 and calcitonin gene-related peptide
Cardiovasc Res, June 1, 2006; 70(3): 589 - 599.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. Mahabir, M. F. Leitzmann, M. J. Virtanen, J. Virtamo, P. Pietinen, D. Albanes, and P. R. Taylor
Prospective Study of Alcohol Drinking and Renal Cell Cancer Risk in a Cohort of Finnish Male Smokers
Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 170 - 175.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Casani, E. Segales, G. Vilahur, A. B. de Luna, and L. Badimon
Moderate Daily Intake of Red Wine Inhibits Mural Thrombosis and Monocyte Tissue Factor Expression in an Experimental Porcine Model
Circulation, July 27, 2004; 110(4): 460 - 465.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
M. K. Malinski, H. D. Sesso, F. Lopez-Jimenez, J. E. Buring, and J. M. Gaziano
Alcohol Consumption and Cardiovascular Disease Mortality in Hypertensive Men
Arch Intern Med, March 22, 2004; 164(6): 623 - 628.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. Bohm, S. Rosenkranz, and U. Laufs
Alcohol and red wine: impact on cardiovascular risk
Nephrol. Dial. Transplant., January 1, 2004; 19(1): 11 - 16.
[Full Text] [PDF]

Home page
 NEJMHome page
K. J. Mukamal, K. M. Conigrave, M. A. Mittleman, C. A. Camargo Jr., M. J. Stampfer, W. C. Willett, and E. B. Rimm
Roles of Drinking Pattern and Type of Alcohol Consumed in Coronary Heart Disease in Men
N. Engl. J. Med., January 9, 2003; 348(2): 109 - 118.
[Abstract] [Full Text] [PDF]

Home page
 Asia Pac J Public HealthHome page
D. Chi, M. Nakano, and K. Yamamoto
Correlates of Serum High-Density Lipoprotein Cholesterol: A Community-Based Study of Middle-Aged and Older Men and Women in Japan
Asia Pac J Public Health, January 1, 2003; 15(1): 17 - 22.
[Abstract] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. L McCullough, D. Feskanich, M. J Stampfer, E. L Giovannucci, E. B Rimm, F. B Hu, D. Spiegelman, D. J Hunter, G. A Colditz, and W. C Willett
Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance
Am. J. Clinical Nutrition, December 1, 2002; 76(6): 1261 - 1271.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Yamaguchi, C. Dayton, T. Shigematsu, P. Carter, T. Yoshikawa, D. C. Gute, and R. J. Korthuis
Preconditioning with ethanol prevents postischemic leukocyte-endothelial cell adhesive interactions
Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1019 - H1030.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. J. Mukamal, M. Maclure, J. E. Muller, J. B. Sherwood, and M. A. Mittleman
Tea Consumption and Mortality After Acute Myocardial Infarction
Circulation, May 28, 2002; 105(21): 2476 - 2481.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
K. J. Mukamal, M. Maclure, J. E. Muller, J. B. Sherwood, and M. A. Mittleman
Prior Alcohol Consumption and Mortality Following Acute Myocardial Infarction
JAMA, April 18, 2001; 285(15): 1965 - 1970.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Djousse, D. Levy, J. M. Murabito, L. A. Cupples, and R. C. Ellison
Alcohol Consumption and Risk of Intermittent Claudication in the Framingham Heart Study
Circulation, December 19, 2000; 102(25): 3092 - 3097.
[Abstract] [Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
H. Numminen, M. Kobayashi, S. Uchiyama, M. Iwata, Y. Ikeda, A. Riutta, M. Syrjala, R. Kekomaki, and M. Hillbom
EFFECTS OF ALCOHOL AND THE EVENING MEAL ON SHEAR-INDUCED PLATELET AGGREGATION AND URINARY EXCRETION OF PROSTANOIDS
Alcohol Alcohol., November 1, 2000; 35(6): 594 - 600.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
M. Gronbaek, U. Becker, D. Johansen, A. Gottschau, P. Schnohr, H. O. Hein, G. Jensen, and T. I.A. Sorensen
Type of Alcohol Consumed and Mortality from All Causes, Coronary Heart Disease, and Cancer
Ann Intern Med, September 19, 2000; 133(6): 411 - 419.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. G. Solomon, F. B. Hu, M. J. Stampfer, G. A. Colditz, F. E. Speizer, E. B. Rimm, W. C. Willett, and J. E. Manson
Moderate Alcohol Consumption and Risk of Coronary Heart Disease Among Women With Type 2 Diabetes Mellitus
Circulation, August 1, 2000; 102(5): 494 - 499.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
U. A. Ajani, J. M. Gaziano, P. A. Lotufo, S. Liu, C. H. Hennekens, J. E. Buring, and J. E. Manson
Alcohol Consumption and Risk of Coronary Heart Disease by Diabetes Status
Circulation, August 1, 2000; 102(5): 500 - 505.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
P.B.S. Fowler
The thyroid, blood flow and atheroma
QJM, July 1, 2000; 93(7): 477 - 485.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
S Agewall, S Wright, R.N Doughty, G.A Whalley, M Duxbury, and N Sharpe
Does a glass of red wine improve endothelial function?
Eur. Heart J., January 1, 2000; 21(1): 74 - 78.
[Abstract] [PDF]

Home page
 CirculationHome page
J. H. Stein, J. G. Keevil, D. A. Wiebe, S. Aeschlimann, and J. D. Folts
Purple Grape Juice Improves Endothelial Function and Reduces the Susceptibility of LDL Cholesterol to Oxidation in Patients With Coronary Artery Disease
Circulation, September 7, 1999; 100(10): 1050 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. H. Criqui and B. A. Golomb
Should Patients With Diabetes Drink to Their Health?
JAMA, July 21, 1999; 282(3): 279 - 280.
[Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. J. Hendrickson, P. A. Cahill, J. V. Sitzmann, and E. M. Redmond
Ethanol Enhances Basal and Flow-Stimulated Nitric Oxide Synthase Activity In Vitro by Activating an Inhibitory Guanine Nucleotide Binding Protein
J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1293 - 1300.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. H. Markovitz, L. Tolbert, and S. E. Winders
Increased Serotonin Receptor Density and Platelet GPIIb/IIIa Activation Among Smokers
Arterioscler Thromb Vasc Biol, March 1, 1999; 19(3): 762 - 766.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. L. Sacco, M. Elkind, B. Boden-Albala, I-F. Lin, D. E. Kargman, W. A. Hauser, S. Shea, and M. C. Paik
The Protective Effect of Moderate Alcohol Consumption on Ischemic Stroke
JAMA, January 6, 1999; 281(1): 53 - 60.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
P C Elwood, S Renaud, A D Beswick, J R O'Brien, and P M Sweetnam
Platelet aggregation and incident ischaemic heart disease in the Caerphilly cohort
Heart, December 1, 1998; 80(6): 578 - 582.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Flesch, A. Schwarz, and M. Bohm
Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries
Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1183 - H1190.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Miyamae, M. M. Rodriguez, S. A. Camacho, I. Diamond, D. Mochly-Rosen, and V. M. Figueredo
Activation of varepsilon  protein kinase C correlates with a cardioprotective effect of regular ethanol consumption
PNAS, July 7, 1998; 95(14): 8262 - 8267.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
W. C. Cushman, J. A. Cutler, E. Hanna, S. F. Bingham, D. Follmann, T. Harford, P. Dubbert, P. S. Allender, M. Dufour, J. F. Collins, et al.
Prevention and Treatment of Hypertension Study (PATHS): Effects of an Alcohol Treatment Program on Blood Pressure
Arch Intern Med, June 8, 1998; 158(11): 1197 - 1207.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. Kiechl, J. Willeit, G. Rungger, G. Egger, F. Oberhollenzer, and E. Bonora
Alcohol Consumption and Atherosclerosis: What Is the Relation? : Prospective Results From the Bruneck Study
Stroke, May 1, 1998; 29(5): 900 - 907.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
R. Doll
One for the heart
BMJ, December 20, 1997; 315(7123): 1664 - 1668.
[Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Miyamae, I. Diamond, M. W. Weiner, S. A. Camacho, and V. M. Figueredo
Regular alcohol consumption mimics cardiac preconditioning by protecting against ischemia-reperfusion injury
PNAS, April 1, 1997; 94(7): 3235 - 3239.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. A. Camargo, M. J. Stampfer, R. J. Glynn, J. M. Gaziano, J. E. Manson, S. Z. Goldhaber, and C. H. Hennekens
Prospective Study of Moderate Alcohol Consumption and Risk of Peripheral Arterial Disease in US Male Physicians
Circulation, February 4, 1997; 95(3): 577 - 580.
[Abstract] [Full Text]

Home page
 Scand J Public HealthHome page
T. Messner and B. Petersson
Alcohol consumption and Ischemic Heart Disease mortality in Sweden
Scand J Public Health, June 1, 1996; 24(2): 107 - 113.
[Abstract] [PDF]

Home page
 BMJHome page
E. B Rimm, A. Klatsky, D. Grobbee, and M. J Stampfer
Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits?
BMJ, March 23, 1996; 312(7033): 731 - 736.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J.-C. Ruf, J.-L. Berger, and S. Renaud
Platelet Rebound Effect of Alcohol Withdrawal and Wine Drinking in Rats : Relation to Tannins and Lipid Peroxidation
Arterioscler Thromb Vasc Biol, January 1, 1995; 15(1): 140 - 144.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by The American Society for Nutrition