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American Journal of Clinical Nutrition, Vol 56, 262S-264S, Copyright © 1992 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Changes in total body nitrogen during weight reduction by very-low- calorie diets

WD Morgan, SJ Ryde, JL Birks, DW Thomas and SN Kreitzman
Department of Medical Physics and Clinical Engineering, Singleton Hospital, Wales, UK.

Body composition measurements, including total body nitrogen (TBN) by in vivo neutron activation analysis, were made on 11 female volunteers before and after an 11-wk very-low-calorie diet (VLCD) [1695 kJ (405 kcal) 6.7 g N]. Mean body mass index (BMI) changed from 32.1 to 26.2 kg/m2, corresponding to a mean weight loss of 16.2 +/- 2.4 (SD) kg. The mean loss of TBN was 125 +/- 57 g, equivalent to 781 +/- 356 g protein. The fat-free mass (FFM) component of the weight loss was calculated by two different methods as 23.5% (+/- 3% SEM) and 22.8% (+/- 2.7% SEM), respectively, thereby demonstrating the improved protein sparing of ketogenic VLCDs. FFM loss was not clearly related to BMI.


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