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American Journal of Clinical Nutrition, Vol 56, 543-547, Copyright © 1992 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Studies on the application of the relative-dose-response test for assessing vitamin A status in older adults

J Bulux, E Carranza, C Castaneda, NW Solomons, LJ Sokoll, FD Morrow and RM Russell
Center for Studies of Sensory Impairment, Aging and Metabolism (CESSIAM), Guatemala City, Guatemala.

We investigated the time course and the reproducibility of the relative- dose-response (RDR) test for assessing vitamin A status in older adults. The maximum plasma retinol response to 480 retinol equivalents (RE) of retinyl palmitate in abnormal responses was at 6 or 7 h after dosing compared with the 5-h sampling interval recommended by others for younger adults and children. With respect to reproducibility, the diagnostic concordance of two RDR tests at 7-d intervals in 14 elders was 71%. In 29% of tests, one test was abnormal and the other normal. Linear regression of the two RDR values in these 14 subjects gave a correlation coefficient of -0.08. We conclude that the procedure for the RDR should be modified when applied to persons greater than 60 y of age, and that multiple repetitions of the test are needed to provide a stable indication of vitamin A stores in an elderly individual.


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J. D Ribaya-Mercado, M. Mazariegos, G. Tang, M. E. Romero-Abal, I. Mena, N. W Solomons, and R. M Russell
Assessment of total body stores of vitamin A in Guatemalan elderly by the deuterated-retinol-dilution method
Am. J. Clinical Nutrition, February 1, 1999; 69(2): 278 - 284.
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Copyright © 1992 by The American Society for Nutrition