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American Journal of Clinical Nutrition, Vol 56, 684-690, Copyright © 1992 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of beta-carotene supplementation on photosuppression of delayed- type hypersensitivity in normal young men

CJ Fuller, H Faulkner, A Bendich, RS Parker and DA Roe
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853.

The aim of this study was to examine whether beta-carotene protects against the immunosuppression seen with long-wave ultraviolet-light (UV- A) exposure. Free-living, healthy men, aged 19-39 y received 30 mg beta- carotene/d or a placebo while on a single-menu, low-carotenoid diet. After 28 d all subjects received 12 exposures to a UV-A/B light source over a 16-d period. The total UV-A dose received ranged from 15.9 to 19.3 J/cm2. The total shorter-wave ultraviolet-light (UV-B) dose varied from 1.59 to 1.96 J/cm2. Follow-up continued for 21 d. Carotenoid assays and delayed-type hypersensitivity (DTH) tests were performed at baseline, pre-UV, post-UV, and after follow-up. The DTH-test responses were significantly suppressed in the placebo group after UV treatments. The suppression was inversely related to plasma beta-carotene concentrations in this group. There was no significant suppression of DTH test responses in the beta-carotene group. It is concluded that beta-carotene protects against photosuppression of immune function.


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