American Journal of Clinical Nutrition, Vol 56, 1019-1024, Copyright © 1992 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Trans-fatty acid intake in relation to serum lipid concentrations in adult men

R Troisi, WC Willett and ST Weiss
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02115.

The relation of trans-fatty acid intake to fasting serum lipid concentrations was evaluated in a cross-sectional study of 748 men aged 43-85 y. Multiple-linear-regression analysis was used to adjust for age, body mass index, waist-to-hip circumference ratio, smoking status, physical activity, alcohol intake, total energy, dietary cholesterol and linoleic acid, and previous serum cholesterol concentration. Trans- fatty acid intake was directly related to total serum (r = 0.07, P = 0.04) and low-density-lipoprotein cholesterol (LDL) (r = 0.09, P = 0.01), and inversely related to high-density-lipoprotein (HDL) cholesterol (r = 0.08, P = 0.03). Trans-fatty acid intake was positively associated with the ratios of total to HDL cholesterol (r = 0.11, P = 0.002) and LDL to HDL cholesterol (r = 0.12, P = 0.001). The estimated ratios of total to HDL cholesterol were 4.4 and 4.9 for persons at the 10th (2.1 g/d) and 90th (4.9 g/d) percentiles of trans- fatty acid intake, respectively. On the basis of results from other studies, these ratios would correspond to a 27% increase in risk of myocardial infarction.

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