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American Journal of Clinical Nutrition, Vol 56, 1056-1060, Copyright © 1992 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Guar gum in insulin-dependent diabetes: effects on glycemic control and serum lipoproteins

H Vuorinen-Markkola, M Sinisalo and VA Koivisto
Second Department of Medicine, Helsinki University Hospital, Finland.

We examined the effect of guar gum on glycemic control and serum lipid and lipoprotein profiles in mildly hypercholesterolemic patients with insulin-dependent diabetes. The study was done in a randomized, double- blind fashion with either guar gum or placebo added to the diet four times per day for 6 wk each. Fasting blood glucose and hemoglobin A1c decreased significantly during the guar-gum diet, whereas the diurnal glucose profile was unchanged. In addition, serum low-density- lipoprotein (LDL) cholesterol decreased by 20% and the ratio of LDL cholesterol to high-density-lipoprotein cholesterol by 28% during guar- gum therapy. No changes were seen in the placebo group. In conclusion, guar gum can improve glycemic control and decrease serum LDL- cholesterol concentrations in mildly hypercholesterolemic insulin- dependent diabetic patients and thus reduce risk factors for both micro- and macroangiopathic complications.


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