American Journal of Clinical Nutrition, Vol 57, 32-34, Copyright © 1993 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Resting metabolic rate in homozygous sickle cell disease

A Singhal, P Davies, A Sahota, PW Thomas and GR Serjeant
Medical Research Council Laboratories, University of the West Indies, Kingston, Jamaica.

The resting metabolic rate in 20 patients with homozygous sickle cell (SS) disease was 19% higher than in 20 age- and sex-matched control subjects with a normal hemoglobin genotype (AA). The difference was not accounted for by differences in lean body mass. It is postulated that this increased energy expenditure reflects the energy expenditure of erythropoietic hyperplasia and leads to a marginal nutritional state that may contribute to the abnormal growth in SS disease.

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