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American Journal of Clinical Nutrition, Vol 57, 154-160, Copyright © 1993 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion

IA Blair, C Prakash, MA Phillips, RM Dougherty and JM Iacono
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232.

A group of women were fed two separate diets in a crossover study and urinary eicosanoids were quantified. One diet contained 3.1% of total energy (en%) as polyunsaturated fatty acids (3.0 en% linoleic acid) and the other contained 8.4 en% polyunsaturated fatty acids (8.3 en% linoleic acid). Carbohydrate replaced fat in the low-polyunsaturated- fat diet. No changes were observed in the urinary excretion of 6-oxo- prostaglandin F1 alpha, its 2,3-dinor metabolite or thromboxane B2 by subjects on either of the diets. Urinary 2,3-dinor-thromboxane B2 excretion was lower (206.5 ng/24 h) when subjects were fed the high- omega 6 polyunsaturated fatty acid diet when compared with the lower- omega 6 polyunsaturated fatty acid diet (275.3 ng/24 h). Conversely, urinary prostaglandin E2 was higher (139.2 ng/g creatinine) during the higher-omega 6 polyunsaturated fatty acid diet when compared with the lower-omega 6 polyunsaturated fatty acid diet (94.4 ng/g creatinine).


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