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American Journal of Clinical Nutrition, Vol 57, 271S-275S, Copyright © 1993 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Selenium deficiency mitigates hypothyroxinemia in iodine-deficient subjects

JB Vanderpas, B Contempre, NL Duale, H Deckx, N Bebe, AO Longombe, CH Thilly, AT Diplock and JE Dumont
Cemubac Medical Team, Public Health School, Free University of Brussels, Belgium.

Studies were performed to assess the role of combined selenium and iodine deficiency in the etiology of endemic myxedematous cretinism in a population in Zaire. One effect of selenium deficiency may be to lower glutathione peroxidase activity in the thyroid gland, thus allowing hydrogen peroxide produced during thyroid hormone synthesis to be cytotoxic. In selenium-and-iodine-deficient humans, selenium supplementation may aggravate hypothyroidism by stimulating thyroxin metabolism by the selenoenzyme type I iodothyronine 5'-deiodinase. Selenium supplementation is thus not indicated without iodine or thyroid hormone supplementation in cases of combined selenium and iodine deficiencies.


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