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American Journal of Clinical Nutrition, Vol 57, 291S-294S, Copyright © 1993 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

5'-Monodeiodinase activity in developing human cerebral cortex

MG Karmarkar, D Prabarkaran and MM Godbole
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi.

Iodine status of aborted fetuses (11-25 wk gestation) was determined on the basis of maternal thyroid status and urinary iodine excretion. Fetal cerebral cortex thyroxin and 3,5,3'-triiodothyronine (T3) contents peaked at 15-18 wk gestation and then fell in iodine sufficiency. In mild iodine deficiency T3 concentration was maintained at a higher level until week 22, although it were still significantly less than in the iodine-sufficient group. Reverse T3 (rT3) rose from 11 to 22 wk gestation without any effect of iodine status. The activity of 5' and 5-monodeiodinase also increased from 11 to 22 wk gestation, with 5' monodeiodinase activity significantly increased by mild and moderate iodine deficiency. In contrast, cerebral cortex 5-monodeiodinase activity was significantly lower in moderate iodine deficiency at 15-18 wk gestation. The observations indicate that cerebral cortex 5' and 5 monodeiodinase activities are modulated in iodine deficiency to enhance T3 production from thyroxin (T4) during the period that coincides with neuroblastogenesis.


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A. G. van Wassenaer, J. M. Briet, A. van Baar, B. J. Smit, P. Tamminga, J. J. M. de Vijlder, and J. H. Kok
Free Thyroxine Levels During the First Weeks of Life and Neurodevelopmental Outcome Until the Age of 5 Years in Very Preterm Infants
Pediatrics, September 1, 2002; 110(3): 534 - 539.
[Abstract] [Full Text] [PDF]


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Copyright © 1993 by The American Society for Nutrition