American Journal of Clinical Nutrition, Vol 57, 408-413, Copyright © 1993 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

A 1-y trial of the effect of high-selenium bread on selenium concentrations in blood and toenails

MP Longnecker, MJ Stampfer, JS Morris, V Spate, C Baskett, M Mason and WC Willett
Department of Epidemiology, University of California, Los Angeles School of Public Health 90024-1772.

The concentration of selenium in toenail clippings and blood reflects dietary intake better than does intake calculated from dietary data because of the highly variable selenium concentration in different samples of the same food. However, the time course of selenium intake in relation to subsequent concentrations in toenail clippings is unclear. Therefore, 12 males were fed high-dose (4.91 mumol Se/d), medium-dose (2.61 mumol Se/d), or control (0.41 mumol Se/d) whole-wheat- bread for 1 y and the concentration of selenium was measured in toenail clippings collected every 12 wk for 2 y. Toenail selenium concentration was unaffected by dietary intake in the previous 3 mo and appeared to provide a time-integrated measure of intake over a period of 26-52 wk. Use of selenium concentration in toenail clippings may be an alternative to blood when a measure of long-term average intake is desired. The absence of a short-term effect of diet on toenail selenium concentration also makes this a useful marker of intake in retrospective studies.

This article has been cited by other articles:

				M. Laclaustra, A. Navas-Acien, S. Stranges, J. M. Ordovas, and E. Guallar Serum Selenium Concentrations and Hypertension in the US Population Circ Cardiovasc Qual Outcomes, July 1, 2009; 2(4): 369 - 376. [Abstract] [Full Text] [PDF]

				J. Bleys, A. Navas-Acien, M. Laclaustra, R. Pastor-Barriuso, A. Menke, J. Ordovas, S. Stranges, and E. Guallar Serum Selenium and Peripheral Arterial Disease: Results From the National Health and Nutrition Examination Survey, 2003-2004 Am. J. Epidemiol., April 15, 2009; 169(8): 996 - 1003. [Abstract] [Full Text] [PDF]

				M. G. Boosalis The Role of Selenium in Chronic Disease Nutr Clin Pract, April 1, 2008; 23(2): 152 - 160. [Abstract] [Full Text] [PDF]

				J. Bleys, A. Navas-Acien, and E. Guallar Serum Selenium Levels and All-Cause, Cancer, and Cardiovascular Mortality Among US Adults Arch Intern Med, February 25, 2008; 168(4): 404 - 410. [Abstract] [Full Text] [PDF]

				J. Bleys, A. Navas-Acien, and E. Guallar Serum Selenium and Diabetes in U.S. Adults Diabetes Care, April 1, 2007; 30(4): 829 - 834. [Abstract] [Full Text] [PDF]

				M. L. Kile, E. A. Houseman, E. Rodrigues, T. J. Smith, Q. Quamruzzaman, M. Rahman, G. Mahiuddin, L. Su, and D. C. Christiani Toenail Arsenic Concentrations, GSTT1 Gene Polymorphisms, and Arsenic Exposure from Drinking Water Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2419 - 2426. [Abstract] [Full Text] [PDF]

				S. Rajpathak, E. Rimm, J. S. Morris, and F. Hu Toenail Selenium and Cardiovascular Disease in Men with Diabetes J. Am. Coll. Nutr., August 1, 2005; 24(4): 250 - 256. [Abstract] [Full Text] [PDF]

				D. J. Waters, S. Shen, L. T. Glickman, D. M. Cooley, D. G. Bostwick, J. Qian, G. F. Combs Jr, and J. S. Morris Prostate cancer risk and DNA damage: translational significance of selenium supplementation in a canine model Carcinogenesis, July 1, 2005; 26(7): 1256 - 1262. [Abstract] [Full Text] [PDF]

				J. W. FINLEY Proposed Criteria for Assessing the Efficacy of Cancer Reduction by Plant Foods Enriched in Carotenoids, Glucosinolates, Polyphenols and Selenocompounds Ann. Bot., June 1, 2005; 95(7): 1075 - 1096. [Abstract] [Full Text] [PDF]

				S. T. Mayne, M. E. Wright, and B. Cartmel Assessment of Antioxidant Nutrient Intake and Status for Epidemiologic Research J. Nutr., November 1, 2004; 134(11): 3199S - 3200S. [Full Text] [PDF]

				S. Rajpathak, E. B. Rimm, T. Li, J. S. Morris, M. J. Stampfer, W. C. Willett, and F. B. Hu Lower Toenail Chromium in Men With Diabetes and Cardiovascular Disease Compared With Healthy Men Diabetes Care, September 1, 2004; 27(9): 2211 - 2216. [Abstract] [Full Text] [PDF]

				H. Zhuo, A. H. Smith, and C. Steinmaus Selenium and Lung Cancer: A Quantitative Analysis of Heterogeneity in the Current Epidemiological Literature Cancer Epidemiol. Biomarkers Prev., May 1, 2004; 13(5): 771 - 778. [Abstract] [Full Text] [PDF]

				S. T. Mayne Antioxidant Nutrients and Chronic Disease: Use of Biomarkers of Exposure and Oxidative Stress Status in Epidemiologic Research J. Nutr., March 1, 2003; 133(3): 933S - 940. [Abstract] [Full Text] [PDF]

				A. M. Y. Nomura, J. Lee, G. N. Stemmermann, and G. F. Combs Jr. Serum Selenium and Subsequent Risk of Prostate Cancer Cancer Epidemiol. Biomarkers Prev., September 1, 2000; 9(9): 883 - 887. [Abstract] [Full Text]

				G. A. Colditz Selenium and Cancer Prevention: Promising Results Indicate Further Trials Required JAMA, December 25, 1996; 276(24): 1984 - 1985. [Abstract] [PDF]

				A. F.M. Kardinaal, A. Aro, J. D. Kark, R. A. Riemersma, P. van 't Veer, J. Gomez-Aracena, L. Kohlmeier, J. Ringstad, B. C. Martin, V. P. Mazaev, et al. Association Between ß-Carotene and Acute Myocardial Infarction Depends on Polyunsaturated Fatty Acid Status : The EURAMIC Study Arterioscler Thromb Vasc Biol, June 1, 1995; 15(6): 726 - 732. [Abstract] [Full Text]