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American Journal of Clinical Nutrition, Vol 57, 420-427, Copyright © 1993 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Hepatic utilization of exogenous nucleotide precursors for restoration of ATP after cold ischemia in rats

JD Palombo, JL Bowers, ME Clouse, A McCullough, RA Forse and BR Bistrian
Department of Surgery, New England Deaconess Hospital-Harvard Medical School, Boston, MA 02215.

The study objective was to assess hepatic utilization of exogenous adenosine or adenine to enhance ATP recovery in rat liver after cold ischemia. ATP was measured noninvasively by 31P nuclear magnetic resonance (NMR) in perfused livers before and after 18 h of cold ischemia. The hepatocellular concentration of ATP during the initial postischemic reperfusion without adenosine or adenine coinfusion was 60% of that in fresh liver. The ATP increased significantly (P < 0.001) to 139% and 82% of baseline in postischemic livers coinfused for 90 min with adenosine or adenine (final concentration, 1 mmol/L), respectively. Less than 0.5% of the excess adenosine was catabolized to uric acid. In conclusion, adenosine and, to a lesser extent, adenine are salvaged by liver after extended cold ischemia to enhance ATP restoration. Provision of these ATP precursors, as components of an enteral formulation may facilitate the repletion of liver ATP and foster early resumption of liver function after an ischemic insult.


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M. J. Perez, F. Sanchez-Medina, M. Torres, A. Gil, and A. Suarez
Dietary Nucleotides Enhance the Liver Redox State and Protein Synthesis in Cirrhotic Rats
J. Nutr., October 1, 2004; 134(10): 2504 - 2508.
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Copyright © 1993 by The American Society for Nutrition