American Journal of Clinical Nutrition, Vol 57, 908-911, Copyright © 1993 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Day-to-day variation of the glycemic response in subjects with insulin- dependent diabetes with standardized premeal blood glucose and prandial insulin concentrations

O Rasmussen
Medical Department M (Diabetes and Endocrinology), Aarhus Kommunehospital, Denmark.

To study the day-to-day variation in the glycemic response to a starch- rich meal in subjects with insulin-dependent diabetes mellitus (IDDM), eight young subjects with IDDM were served test meals of 100 g white bread on 3 separate days. They had achieved normoglycemia 2 h before the test meals by means of a glucose clamp and a constant insulin infusion was provided during the study period. Mean areas under the response curves of blood glucose to the three meals (above basal) were not different: 1067 +/- 93, 1028 +/- 91, and 970 +/- 42 mmol/L x 180 min (NS) and no difference in insulin concentrations was found. The mean (+/- 95% confidence interval) of blood glucose area under the response curves for one test meal was 1067 +/- 230 mmol/L x 180 min and for the test meal repeated three times was 1021 +/- 133 mmol/L x 180 min. Intra- and interperson components of variance were 26% and 74%, respectively, of the total variance of blood glucose areas.

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