| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 58, 754S-765S, Copyright © 1993 by The American Society for Clinical Nutrition, Inc
REVIEW ARTICLES |
PA Mayes
Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, UK.
Most of the metabolic effects of fructose are due to its rapid utilization by the liver and it by-passing the phosphofructokinase regulatory step in glycolysis, leading to far reaching consequences to carbohydrate and lipid metabolism. These consequences include immediate hepatic increases in pyruvate and lactate production, activation of pyruvate dehydrogenase, and a shift in balance from oxidation to esterification of nonesterified fatty acids, resulting in increased secretion of very-low-density-lipoprotein (VLDL). These effects are augmented by long-term absorption of fructose, which causes enzyme adaptations that increase lipogenesis and VLDL secretion, leading to triglyceridemia, decreased glucose tolerance, and hyperinsulinemia. Acute loading of the liver with fructose causes sequestration of inorganic phosphate in fructose-1-phosphate and diminished ATP synthesis. Consequently, the inhibition by ATP of the enzymes of adenine nucleotide degradation is removed and uric acid formation accelerates with consequent hyperuricemia. These effects are of particular significance to potentially hypertriglyceridemic or hyperuricemic individuals.
This article has been cited by other articles:
|
|
 |
|
  M. F-F Chong, B. A Fielding, and K. N Frayn Mechanisms for the acute effect of fructose on postprandial lipemia Am. J. Clinical Nutrition, June 1, 2007; 85(6): 1511 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Huang, N. Dedousis, and R. M. O'Doherty Hepatic steatosis and plasma dyslipidemia induced by a high-sucrose diet are corrected by an acute leptin infusion J Appl Physiol, June 1, 2007; 102(6): 2260 - 2265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Griel, E. H. Ruder, and P. M. Kris-Etherton The Changing Roles of Dietary Carbohydrates: From Simple to Complex Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 1958 - 1965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wei, D. Wang, and M. J. Pagliassotti Fructose Selectively Modulates c-jun N-Terminal Kinase Activity and Insulin Signaling in Rat Primary Hepatocytes J. Nutr., July 1, 2005; 135(7): 1642 - 1646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shiota, P. Galassetti, K. Igawa, D. W. Neal, and A. D. Cherrington Inclusion of low amounts of fructose with an intraportal glucose load increases net hepatic glucose uptake in the presence of relative insulin deficiency in dog Am J Physiol Endocrinol Metab, June 1, 2005; 288(6): E1160 - E1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cordain, S B. Eaton, A. Sebastian, N. Mann, S. Lindeberg, B. A Watkins, J. H O'Keefe, and J. Brand-Miller Origins and evolution of the Western diet: health implications for the 21st century Am. J. Clinical Nutrition, February 1, 2005; 81(2): 341 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wei and M. J. Pagliassotti Hepatospecific effects of fructose on c-jun NH2-terminal kinase: implications for hepatic insulin resistance Am J Physiol Endocrinol Metab, November 1, 2004; 287(5): E926 - E933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Bertolini, A L Moyer, J B Mason, C A Batchelder, K A Hoffert, L R Bertolini, G F Carneiro, S L Cargill, T R Famula, C C Calvert, et al. Evidence of increased substrate availability to in vitro-derived bovine foetuses and association with accelerated conceptus growth Reproduction, September 1, 2004; 128(3): 341 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Suzuki and H. Hara Ingestion of Guar Gum Hydrolysate, a Soluble and Fermentable Nondigestible Saccharide, Improves Glucose Intolerance and Prevents Hypertriglyceridemia in Rats Fed Fructose J. Nutr., August 1, 2004; 134(8): 1942 - 1947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A Bray, S. J. Nielsen, and B. M Popkin Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity Am. J. Clinical Nutrition, April 1, 2004; 79(4): 537 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Busserolles, E. Gueux, E. Rock, C. Demigne, A. Mazur, and Y. Rayssiguier Oligofructose Protects against the Hypertriglyceridemic and Pro-oxidative Effects of a High Fructose Diet in Rats J. Nutr., June 1, 2003; 133(6): 1903 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S Treuth, A. L Sunehag, L. M Trautwein, D. M Bier, M. W Haymond, and N. F Butte Metabolic adaptation to high-fat and high-carbohydrate diets in children and adolescents Am. J. Clinical Nutrition, February 1, 2003; 77(2): 479 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Pagliassotti, Y. Wei, and M. E. Bizeau Glucose-6-Phosphatase Activity Is Not Suppressed but the mRNA Level Is Increased by a Sucrose-Enriched Meal in Rats J. Nutr., January 1, 2003; 133(1): 32 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Busserolles, E. Gueux, E. Rock, A. Mazur, and Y. Rayssiguier Substituting Honey for Refined Carbohydrates Protects Rats from Hypertriglyceridemic and Prooxidative Effects of Fructose J. Nutr., November 1, 2002; 132(11): 3379 - 3382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Haidari, N. Leung, F. Mahbub, K. D. Uffelman, R. Kohen-Avramoglu, G. F. Lewis, and K. Adeli Fasting and Postprandial Overproduction of Intestinally Derived Lipoproteins in an Animal Model of Insulin Resistance. EVIDENCE THAT CHRONIC FRUCTOSE FEEDING IN THE HAMSTER IS ACCOMPANIED BY ENHANCED INTESTINAL DE NOVO LIPOGENESIS AND ApoB48-CONTAINING LIPOPROTEIN OVERPRODUCTION J. Biol. Chem., August 23, 2002; 277(35): 31646 - 31655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. W. Wolf, P. M. Humphrey, C. W. Hadley, K. S. Maharry, K. A. Garleb, and J. L. Firkins Supplemental Fructose Attenuates Postprandial Glycemia in Zucker Fatty fa/fa Rats J. Nutr., June 1, 2002; 132(6): 1219 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shiota, M. C. Moore, P. Galassetti, M. Monohan, D. W. Neal, G. I. Shulman, and A. D. Cherrington Inclusion of Low Amounts of Fructose With an Intraduodenal Glucose Load Markedly Reduces Postprandial Hyperglycemia and Hyperinsulinemia in the Conscious Dog Diabetes, February 1, 2002; 51(2): 469 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Pagliassotti, J. Kang, J. S. Thresher, C. K. Sung, and M. E. Bizeau Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E170 - E176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M McDevitt, S. J Bott, M. Harding, W A. Coward, L. J Bluck, and A. M Prentice De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women Am. J. Clinical Nutrition, December 1, 2001; 74(6): 737 - 746. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Jiang, E. S. David, N. Espina, and R. P. Ferraris GLUT-5 expression in neonatal rats: crypt-villus location and age-dependent regulation Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G666 - G674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Bizeau, J. S. Thresher, and M. J. Pagliassotti A high-sucrose diet increases gluconeogenic capacity in isolated periportal and perivenous rat hepatocytes Am J Physiol Endocrinol Metab, May 1, 2001; 280(5): E695 - E702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dirlewanger, P. Schneiter, E. Jequier, and L. Tappy Effects of fructose on hepatic glucose metabolism in humans Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E907 - E911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E Daly, C. Vale, M. Walker, A. Littlefield, K George, M. Alberti, and J. Mathers Acute fuel selection in response to high-sucrose and high-starch meals in healthy men Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1516 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Lingelbach, A. E. Mitchell, R. B. Rucker, and R. B. McDonald Accumulation of Advanced Glycation Endproducts in Aging Male Fischer 344 Rats during Long-Term Feeding of Various Dietary Carbohydrates J. Nutr., May 1, 2000; 130(5): 1247 - 1255. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
