American Journal of Clinical Nutrition, Vol 59, 115-122, Copyright © 1994 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Lipid-lowering diets enriched with monounsaturated or polyunsaturated fatty acids but low in saturated fatty acids have similar effects on serum lipid concentrations in hyperlipidemic patients

MC Nydahl, IB Gustafsson and B Vessby
Department of Geriatrics, University of Uppsala, Sweden.

The aim of this study was to compare the effects of a diet enriched with monounsaturated (MUFAs) with one enriched with polyunsaturated (PUFAs) fatty acids on the serum lipoprotein composition in patients with hyperlipidemia. A new model for conducting controlled dietary treatment studies in free-living hyperlipidemic patients was tested. Twenty-six patients with an average age of 51 y participated in a crossover study during two consecutive 3.5-wk treatment periods. The mean serum cholesterol and LDL cholesterol decreased by 17% and 19%, respectively, on the MUFA diet. The corresponding figures on the PUFA diet were 19% and 23%, respectively. The HDL-cholesterol concentration was significantly decreased after both dietary periods. No significant differences in any of the variables studied were found between the diets. It is concluded that MUFAs and PUFAs, within a diet with a restricted content of saturated fat and total fat, are interchangeable with regard to lipid-lowering effects among free-living hyperlipidemic patients.

This article has been cited by other articles:

				S. Dodin, A. Lemay, H. Jacques, F. Legare, J.-C. Forest, and B. Masse The Effects of Flaxseed Dietary Supplement on Lipid Profile, Bone Mineral Density, and Symptoms in Menopausal Women: A Randomized, Double-Blind, Wheat Germ Placebo-Controlled Clinical Trial J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1390 - 1397. [Abstract] [Full Text] [PDF]

				T. Tholstrup, L. I. Hellgren, M. Petersen, S. Basu, E. M. Straarup, P. Schnohr, and B. Sandstrom A Solid Dietary Fat Containing Fish Oil Redistributes Lipoprotein Subclasses without Increasing Oxidative Stress in Men J. Nutr., May 1, 2004; 134(5): 1051 - 1057. [Abstract] [Full Text] [PDF]

				E. Beauchesne-Rondeau, A. Gascon, J. Bergeron, and H. Jacques Plasma lipids and lipoproteins in hypercholesterolemic men fed a lipid-lowering diet containing lean beef, lean fish, or poultry Am. J. Clinical Nutrition, March 1, 2003; 77(3): 587 - 593. [Abstract] [Full Text] [PDF]

				P. M. Kris-Etherton AHA Science Advisory: Monounsaturated Fatty Acids and Risk of Cardiovascular Disease J. Nutr., December 1, 1999; 129(12): 2280 - 2284. [Full Text]

				P. M. Kris-Etherton Monounsaturated Fatty Acids and Risk of Cardiovascular Disease Circulation, September 14, 1999; 100(11): 1253 - 1258. [Full Text] [PDF]

				T. J. Howell, D. E. MacDougall, and P. J. H. Jones Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding J. Lipid Res., April 1, 1998; 39(4): 892 - 900. [Abstract] [Full Text]

				V. Ruiz-Gutiérrez, N. Morgado, J. L. Prada, F. Pérez-Jiménez, and F. J. G. Muriana Composition of Human VLDL Triacylglycerols after Ingestion of Olive Oil and High Oleic Sunflower Oil J. Nutr., March 1, 1998; 128(3): 570 - 576. [Abstract] [Full Text]

				C. D. Gardner and H. C. Kraemer Monounsaturated Versus Polyunsaturated Dietary Fat and Serum Lipids : A Meta-analysis Arterioscler Thromb Vasc Biol, November 1, 1995; 15(11): 1917 - 1927. [Abstract] [Full Text]

				E. J. Schaefer, A. H. Lichtenstein, S. Lamon-Fava, J. H. Contois, Z. Li, H. Rasmussen, J. R. McNamara, and J. M. Ordovas Efficacy of a National Cholesterol Education Program Step 2 Diet in Normolipidemic and Hypercholesterolemic Middle-Aged and Elderly Men and Women Arterioscler Thromb Vasc Biol, August 1, 1995; 15(8): 1079 - 1085. [Abstract] [Full Text]