Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease [published erratum appears in Am J Clin Nutr 1996 Apr;63(4):609]

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Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease [published erratum appears in Am J Clin Nutr 1996 Apr;63(4):609]

N Pancharuniti, CA Lewis, HE Sauberlich, LL Perkins, RC Go, JO Alvarez, M Macaluso, RT Acton, RB Copeland and AL Cousins
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham 35294-0008.

High plasma homocyst(e)ine (Hcy) concentrations may be a determinant of coronary artery disease (CAD). Folate and vitamin B-12 are required for the primary metabolic pathway to reduce Hcy concentrations. The interrelationships of Hcy and these two vitamin cofactors were investigated in a case-control study of 101 white males aged 30-50 y with angiographically demonstrated CAD, and 108 white male, similarly aged, control subjects living in the same community as the patients. The odds ratio (OR) of CAD per quartile increase of plasma Hcy concentration based on control values was 1.6 (95% CI: 1.3, 2.1). After age, HDL and LDL cholesterol, body mass index, smoking, hypertension, and diabetes were controlled for, Hcy remained an independent risk factor (OR: 1.4; 95% CI: 1.0, 2.0). The OR change per quartile increase of folate concentration was 0.8 (95% CI: 0.6, 1.0). This difference was reduced (OR: 0.9; 95% CI: 0.7, 1.2) after Hcy adjustment. No difference in the geometric mean of vitamin B-12 concentration was found between patients and control subjects, both 5.8 nmol/L. However, after Hcy and the other CAD risk factors were controlled for, the OR per quartile increase in vitamin B-12 concentration was 1.5 (95% CI: 1.0, 1.8). Reduction in plasma Hcy by interventions to increase plasma folate concentration may decrease CAD risk.

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				M.C. Verhaar, E. Stroes, and T.J. Rabelink Folates and Cardiovascular Disease Arterioscler. Thromb. Vasc. Biol., January 1, 2002; 22(1): 6 - 13. [Abstract] [Full Text] [PDF]

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				N. Matsuyama, M. Yamaguchi, M. Toyosato, M. Takayama, and K. Mizuno New Enzymatic Colorimetric Assay for Total Homocysteine Clin. Chem., December 1, 2001; 47(12): 2155 - 2156. [Full Text] [PDF]

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ORIGINAL RESEARCH COMMUNICATIONS

Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease [published erratum appears in Am J Clin Nutr 1996 Apr;63(4):609]

				S.-M. Saw, J.-M. Yuan, C.-N. Ong, K. Arakawa, H.-P. Lee, G. A Coetzee, and M. C Yu Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore Am. J. Clinical Nutrition, February 1, 2001; 73(2): 232 - 239. [Abstract] [Full Text] [PDF]

				Y. Jang, J. H. Lee, E. Y. Cho, N. S. Chung, D. Topham, and B. Balderston Differences in body fat distribution and antioxidant status in Korean men with cardiovascular disease with or without diabetes Am. J. Clinical Nutrition, January 1, 2001; 73(1): 68 - 74. [Abstract] [Full Text] [PDF]

				R. M. Krauss, R. H. Eckel, B. Howard, L. J. Appel, S. R. Daniels, R. J. Deckelbaum, J. W. Erdman Jr, P. Kris-Etherton, I. J. Goldberg, T. A. Kotchen, et al. AHA Scientific Statement: AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association J. Nutr., January 1, 2001; 131(1): 132 - 146. [Full Text]

				C. M. Loria, D. D. Ingram, J. J. Feldman, J. D. Wright, and J. H. Madans Serum Folate and Cardiovascular Disease Mortality Among US Men and Women Arch Intern Med, November 27, 2000; 160(21): 3258 - 3262. [Abstract] [Full Text] [PDF]

				R. M. Fleming and L. B. Boyd The Effect of High-Protein Diets on Coronary Blood Flow Angiology, October 1, 2000; 51(10): 817 - 826. [Abstract] [PDF]

				L. Brattstrom and D. E. Wilcken Homocysteine and cardiovascular disease: cause or effect? Am. J. Clinical Nutrition, August 1, 2000; 72(2): 315 - 323. [Abstract] [Full Text] [PDF]

				G. L. Booth, E. E.L. Wang, and with the Canadian Task Force on Preventive Health Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events Can. Med. Assoc. J., July 1, 2000; 163(1): 21 - 29. [Abstract] [Full Text] [PDF]

				L. J Riddell, A. Chisholm, S. Williams, and J. I Mann Dietary strategies for lowering homocysteine concentrations Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1448 - 1454. [Abstract] [Full Text] [PDF]

				W. G. Christen, U. A. Ajani, R. J. Glynn, and C. H. Hennekens Blood Levels of Homocysteine and Increased Risks of Cardiovascular Disease: Causal or Casual? Arch Intern Med, February 28, 2000; 160(4): 422 - 434. [Abstract] [Full Text] [PDF]

				H. H. Yu, R. Joubran, M. Asmi, T. Law, A. Spencer, M. Jouma, and N. Rifai Agreement among Four Homocysteine Assays and Results in Patients with Coronary Atherosclerosis and Controls Clin. Chem., February 1, 2000; 46(2): 258 - 264. [Abstract] [Full Text] [PDF]