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American Journal of Clinical Nutrition, Vol 59, 1270-1274, Copyright © 1994 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Efficacy of water-soluble vitamin E in the treatment of vitamin E malabsorption in short-bowel syndrome

MG Traber, TD Schiano, AC Steephen, HJ Kayden and M Shike
GI-Nutrition Service Department of Medicine, Memorial Sloan-Kettering Cancer Center, Cornell University Medical College, New York, NY.

A water-soluble form of vitamin E, tocopheryl succinate polyethylene glycol 1000 (TPGS), was used as an oral vitamin E supplement in a 71-y- old patient with severe fat malabsorption and vitamin E deficiency secondary to short-bowel syndrome. An absorption test with deuterium- labeled TPGS demonstrated that TPGS was absorbed and the released alpha- tocopherol was transported normally in lipoproteins. The disappearance portion of the deuterated alpha-tocopherol curves were parallel to those in control subjects, suggesting normal metabolic turnover of alpha-tocopherol. Long-term (3 y) supplementation with orally administered TPGS (10,360 mg or 4000 IU/d) maintained normal plasma alpha-tocopherol concentrations, raised adipose tissue alpha-tocopherol concentrations, and prevented further progression of the neurological abnormalities resulting from vitamin E deficiency. Thus, TPGS can be an effective vitamin E supplement in short-bowel syndrome despite severe fat malabsorption.


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M. G Traber
Reply to H Hemila and ER Miller III
Am. J. Clinical Nutrition, July 1, 2007; 86(1): 263 - 264.
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