AJCN EB Program 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Paolisso, G.
Right arrow Articles by D'Onofrio, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paolisso, G.
Right arrow Articles by D'Onofrio, F.
Agricola
Right arrow Articles by Paolisso, G.
Right arrow Articles by D'Onofrio, F.

American Journal of Clinical Nutrition, Vol 59, 1291-1296, Copyright © 1994 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Pharmacological doses of vitamin E and insulin action in elderly subjects

G Paolisso, G Di Maro, D Galzerano, F Cacciapuoti, G Varricchio, M Varricchio and F D'Onofrio
Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy.

Twenty elderly (77 +/- 0.4 y), nonobese [body mass index (in kg/m2) 26.4 +/- 0.5] subjects with normal glucose tolerance were submitted to a euglycemic hyperinsulinemic (3.5 pmol.min/kg) glucose clamp in a double-blind, crossover, randomized procedure after 4 mo treatment with either vitamin E (900 mg d-alpha-tocopherol/d, Ephynal; Roche, Milan, Italy) or placebo. Body mass index was practically unchanged throughout the study. After the glucose clamp, insulin-mediated stimulation 2 of whole-body glucose disposal (18.4 +/- 0.5 vs 26.1 +/- 0.6 mumol.min/kg lean body mass P < 0.02) was significantly potentiated by vitamin E rather than placebo administration. Furthermore, net changes in plasma vitamin E concentrations correlated with net changes in insulin- stimulated whole-body glucose disposal (r = 0.60 P < 0.003). Plasma vitamin E concentrations seem to play an important role in the modulation of insulin action in elderly people.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
N. Bashan, J. Kovsan, I. Kachko, H. Ovadia, and A. Rudich
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
Physiol Rev, January 1, 2009; 89(1): 27 - 71.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
P. J. Manning, W. H.F. Sutherland, R. J. Walker, S. M. Williams, S. A. de Jong, A. R. Ryalls, and E. A. Berry
Effect of High-Dose Vitamin E on Insulin Resistance and Associated Parameters in Overweight Subjects
Diabetes Care, September 1, 2004; 27(9): 2166 - 2171.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A. E Millen, R. Klein, A. R Folsom, J. Stevens, M. Palta, and J. A Mares
Relation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study
Am. J. Clinical Nutrition, May 1, 2004; 79(5): 865 - 873.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
J. Montonen, P. Knekt, R. Jarvinen, and A. Reunanen
Dietary Antioxidant Intake and Risk of Type 2 Diabetes
Diabetes Care, February 1, 2004; 27(2): 362 - 366.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
A. E. Millen, M. Gruber, R. Klein, B. E. K. Klein, M. Palta, and J. A. Mares
Relations of Serum Ascorbic Acid and {alpha}-Tocopherol to Diabetic Retinopathy in the Third National Health and Nutrition Examination Survey
Am. J. Epidemiol., August 1, 2003; 158(3): 225 - 233.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
K. Ylonen, G. Alfthan, L. Groop, C. Saloranta, A. Aro, S. M Virtanen, and the Botnia Research Group
Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study
Am. J. Clinical Nutrition, June 1, 2003; 77(6): 1434 - 1441.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
D. Manzella, M. Barbieri, E. Ragno, and G. Paolisso
Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes
Am. J. Clinical Nutrition, June 1, 2001; 73(6): 1052 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
F. S Facchini, M. H Humphreys, C. A DoNascimento, F. Abbasi, and G. M Reaven
Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols
Am. J. Clinical Nutrition, September 1, 2000; 72(3): 776 - 779.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Paolisso, M. R. Tagliamonte, M. Barbieri, G. A. Zito, A. Gambardella, G. Varricchio, E. Ragno, and M. Varricchio
Chronic Vitamin E Administration Improves Brachial Reactivity and Increases Intracellular Magnesium Concentration in Type II Diabetic Patients
J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 109 - 115.
[Abstract] [Full Text]

Home page
 HypertensionHome page
M. Barbagallo, L. J. Dominguez, M. R. Tagliamonte, L. M. Resnick, and G. Paolisso
Effects of Vitamin E and Glutathione on Glucose Metabolism : Role of Magnesium
Hypertension, October 1, 1999; 34(4): 1002 - 1006.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by The American Society for Nutrition