AJCN Cancer Health Disparities Conference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, H.
Right arrow Articles by Ney, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, H.
Right arrow Articles by Ney, D. M.
Agricola
Right arrow Articles by Yang, H.
Right arrow Articles by Ney, D. M.

American Journal of Clinical Nutrition, Vol 59, 1403-1408, Copyright © 1994 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Insulin-like growth factor-I (IGF-I) responses in rats maintained with intravenous or intragastric infusion of total parenteral nutrition solutions containing medium- or long-chain triglyceride emulsions

H Yang and DM Ney
Department of Nutritional Sciences, University of Wisconsin-Madison 53706.

Our objective was to determine how intravenous or intragastric feeding affects serum concentrations of insulin-like growth factor (IGF)-I and - II and IGF binding proteins (IGFBP), and hepatic abundance of IGF-I mRNA. Male Fischer 344 rats (235-246 g) were fed for 14 d by intravenous or intragastric infusion with total parenteral nutrition (TPN) solutions providing 65% of energy from long-chain triglyceride (LCT) or a 3:1 admixture of medium-chain triglyceride (MCT) and LCT emulsions (MCT/LCT). Twice as much TPN solution was required per gram of weight gain with MCT/LCT compared with LCT infusion (P < 0.0003). Serum IGF-I and -II concentrations and hepatic IGF-I mRNA abundance were not significantly different. Circulating concentrations of IGFBPs with molecular weights of 38,000-43,000 (IGFBP-3) were significantly greater with intravenous MCT/LCT than with intravenous LCT infusion. Our data demonstrate that reduced growth in rats given TPN containing MCT/LCT compared with LCT emulsions is not associated with reduced serum IGF-I concentrations or hepatic abundance of IGF-I mRNA, although serum IGFBPs are elevated.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. N. Alexander and H. V. Carey
Oral IGF-I enhances nutrient and electrolyte absorption in neonatal piglet intestine
Am J Physiol Gastrointest Liver Physiol, September 1, 1999; 277(3): G619 - G625.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by The American Society for Nutrition