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American Journal of Clinical Nutrition, Vol 6, 26-29, Copyright © 1958 by The American Society for Clinical Nutrition, Inc.

Effect of Intrinsic Factor on Absorption of Vitamin B12 in Healthy Individuals

LEON ELLENBOGEN PH.D.1, BACON F. CHOW PH.D.1, and WILLIAM L. WILLIAMS PH.D.1

1 From the Nutrition and Physiology Section, Research Division, American Cyanamid Company, Pearl River, New York

Capsules containing several hematinic agents including intrinsic factor and vitamin B12 were administered to clinically healthy males. The intrinsic factor concentrate studied did not inhibit absorption of vitamin B12 as has been reported for some other preparations, but caused a slight increase in absorption of the vitamin, in seven consecutive experiments as measured by the urinary excretion tests. In a separate experiment the capsules containing intrinsic factor administered over a period of 12 weeks caused a marked and statistically significant increase in vitamin B12 serum levels.






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Copyright © 1958 by The American Society for Nutrition