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American Journal of Clinical Nutrition, Vol 6, 34-49, Copyright © 1958 by The American Society for Clinical Nutrition, Inc.

Studies on the Mechanism of Action of Vitamin B12 in Animal Nutrition

B. CONNOR JOHNSON PH.D.1

1 From the Laboratory of Animal Biochemistry, Department of Animal Science, University of Illinois, Urbana, Illinois

It appears that vitamin B12 is not directly involved in transmethylation in the animal body nor in the biosynthesis of liver ribose or desoxyribose nucleic acids. On the other hand, vitamin B12 is definitely required for methyl group synthesis from various one-carbon precursors including serine, glycine, formate, and formaldehyde, and its role in one-carbon metabolism appears to influence the incorporation of certain one-carbon compounds into the uric acid excreted by the chick. Preliminary evidence indicates the involvement of vitamin B12 in protein synthesis.






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Copyright © 1958 by The American Society for Nutrition