American Journal of Clinical Nutrition, Vol 60, 100-105, Copyright © 1994 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

High plasma vitamin C associated with high plasma HDL- and HDL2 cholesterol

J Hallfrisch, VN Singh, DC Muller, H Baldwin, ME Bannon and R Andres
Carbohydrate Nutrition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, USDA, Beltsville, MD.

High plasma vitamin C may lower risk of cardiovascular disease as indicated by direct association with plasma high-density-lipoprotein (HDL) cholesterol and HDL2 cholesterol. Plasma lipids and vitamin C were determined in 316 women and 511 men (aged 19-95 y). After adjustment for age, sex, obesity, and smoking, plasma vitamin C was directly associated with HDL- (P = 0.01) and HDL2 cholesterol (P = 0.0002). When men and women with diseases that might affect lipids were excluded, associations between plasma vitamin C and HDL- and HDL2 cholesterol persisted, though the relationships were strongest in older men. Comparisons of diets in a subset (n = 485) who completed 7-d diet records were made. Total fat, saturated fatty acids, energy from fat, and cholesterol intakes were not associated with plasma vitamin C. Mean intakes of vitamin C were well above recommended dietary allowances. These findings suggest that high plasma concentrations of vitamin C may lower atherogenic risk.

This article has been cited by other articles:

				L. Zhang, M. H Gail, Y.-q. Wang, L. M. Brown, K.-f. Pan, J.-l. Ma, H. Amagase, W.-c. You, and R. Moslehi A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins. Am. J. Clinical Nutrition, October 1, 2006; 84(4): 912 - 919. [Abstract] [Full Text] [PDF]

				J. A. Simon, M. A. Murtaugh, M. D. Gross, C. M. Loria, S. B. Hulley, and D. R. Jacobs Jr. Relation of Ascorbic Acid to Coronary Artery Calcium: The Coronary Artery Risk Development in Young Adults Study Am. J. Epidemiol., March 15, 2004; 159(6): 581 - 588. [Abstract] [Full Text] [PDF]

				C. Sanchez-Moreno, M P. Cano, B. de Ancos, L. Plaza, B. Olmedilla, F. Granado, and A. Martin Effect of orange juice intake on vitamin C concentrations and biomarkers of antioxidant status in humans Am. J. Clinical Nutrition, September 1, 2003; 78(3): 454 - 460. [Abstract] [Full Text] [PDF]

				J. A. Simon, E. S. Hudes, and J. A. Tice Relation of Serum Ascorbic Acid to Mortality Among US Adults J. Am. Coll. Nutr., June 1, 2001; 20(3): 255 - 263. [Abstract] [Full Text] [PDF]

				M. Langlois, D. Duprez, J. Delanghe, M. De Buyzere, and D. L. Clement Serum Vitamin C Concentration Is Low in Peripheral Arterial Disease and Is Associated With Inflammation and Severity of Atherosclerosis Circulation, April 10, 2001; 103(14): 1863 - 1868. [Abstract] [Full Text] [PDF]

				N. Gokce, J. F. Keaney Jr, B. Frei, M. Holbrook, M. Olesiak, B. J. Zachariah, C. Leeuwenburgh, J. W. Heinecke, and J. A. Vita Long-Term Ascorbic Acid Administration Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease Circulation, June 29, 1999; 99(25): 3234 - 3240. [Abstract] [Full Text] [PDF]

				A. C Carr and B. Frei Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans Am. J. Clinical Nutrition, June 1, 1999; 69(6): 1086 - 1107. [Abstract] [Full Text] [PDF]

				H. Alexander, L. P. Lockwood, M. A. Harris, and C. L. Melby Risk Factors for Cardiovascular Disease and Diabetes in Two Groups of Hispanic Americans with Differing Dietary Habits J. Am. Coll. Nutr., April 1, 1999; 18(2): 127 - 136. [Abstract] [Full Text] [PDF]

				J. A. Simon and E. S. Hudes Relation of Serum Ascorbic Acid to Serum Lipids and Lipoproteins in US Adults J. Am. Coll. Nutr., June 1, 1998; 17(3): 250 - 255. [Abstract] [Full Text] [PDF]