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American Journal of Clinical Nutrition, Vol 60, 2-11, Copyright © 1994 by The American Society for Clinical Nutrition, Inc


ORIGINAL RESEARCH COMMUNICATIONS

Prevalence of cobalamin deficiency in the Framingham elderly population

J Lindenbaum, IH Rosenberg, PW Wilson, SP Stabler and RH Allen
Department of Medicine, Columbia-Presbyterian Medical Center, New York, NY 10032.

To determine whether the increased prevalence of low serum cobalamin concentrations in elderly people represents true deficiency, serum concentrations of cobalamin and folate and of metabolites that are sensitive indicators of cobalamin deficiency were measured in 548 surviving members of the original Framingham Study cohort. Serum cobalamin concentrations < 258 pmol/L were found in 222 subjects (40.5%) compared with 17.9% of younger control subjects (P < 0.001). Serum methylmalonic acid and total homocysteine concentrations were markedly elevated in association with cobalamin values < 258 pmol/L in 11.3% and 5.7%, respectively, of the cohort. Both metabolites were increased in 3.8% of the cohort, associated with significantly lower erythrocyte counts and higher mean cell volumes. Serum metabolites correlated best with serum cobalamin values, even when subnormal determinations were excluded. The prevalence of cobalamin deficiency was > or = 12% in a large sample of free-living elderly Americans. Many elderly people with "normal" serum vitamin concentrations are metabolically deficient in cobalamin or folate.


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Plasma atherogenic markers in congestive heart failure and posttransplant (heart) patients
J. Am. Coll. Cardiol., August 1, 2000; 36(2): 509 - 516.
[Abstract] [Full Text] [PDF]


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J Neuropsychiatry Clin NeurosciHome page
N. Goebels and M. Soyka
Dementia Associated With Vitamin B12 Deficiency: Presentation of Two Cases and Review of the Literature
J Neuropsychiatry Clin Neurosci, August 1, 2000; 12(3): 389 - 394.
[Abstract] [Full Text]


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CMAJHome page
G. L. Booth, E. E.L. Wang, and with the Canadian Task Force on Preventive Health
Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events
Can. Med. Assoc. J., July 1, 2000; 163(1): 21 - 29.
[Abstract] [Full Text] [PDF]


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J. Am. Coll. Nutr.Home page
J.-C. Essama-Tjani, J.-C. Guilland, G. Potier de Courcy, F. Fuchs, and D. Richard
Folate Status Worsens in Recently Institutionalized Elderly People without Evidence of Functional Deterioration
J. Am. Coll. Nutr., June 1, 2000; 19(3): 392 - 404.
[Abstract] [Full Text] [PDF]


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NEJMHome page
J. L. Mills
Fortification of Foods with Folic Acid -- How Much is Enough?
N. Engl. J. Med., May 11, 2000; 342(19): 1442 - 1445.
[Full Text]


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Am. J. PsychiatryHome page
B. W.J.H. Penninx, J. M. Guralnik, L. Ferrucci, L. P. Fried, R. H. Allen, and S. P. Stabler
Vitamin B12 Deficiency and Depression in Physically Disabled Older Women: Epidemiologic Evidence From the Women's Health and Aging Study
Am J Psychiatry, May 1, 2000; 157(5): 715 - 721.
[Abstract] [Full Text]


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CMAJHome page
F. Anello
Vitamin B12 injections for the elderly
Can. Med. Assoc. J., May 1, 2000; 162(9): 1274 - 1275.
[Full Text] [PDF]


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CMAJHome page
C. G. van Walraven and C. D. Naylor
Vitamin B12 injections for the elderly
Can. Med. Assoc. J., May 1, 2000; 162(9): 1275 - 1276.
[Full Text] [PDF]


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Am. J. Clin. Nutr.Home page
K. L Tucker, S. Rich, I. Rosenberg, P. Jacques, G. Dallal, P. W. Wilson, and J. Selhub
Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study1
Am. J. Clinical Nutrition, February 1, 2000; 71(2): 514 - 522.
[Abstract] [Full Text] [PDF]


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J. Am. Coll. Nutr.Home page
R. D. Lindeman, L. J. Romero, K. M. Koehler, H. C. Liang, A. LaRue, R. N. Baumgartner, and P. J. Garry
Serum Vitamin B12, C and Folate Concentrations in the New Mexico Elder Health Survey: Correlations with Cognitive and Affective Functions
J. Am. Coll. Nutr., February 1, 2000; 19(1): 68 - 76.
[Abstract] [Full Text] [PDF]


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Am. J. Clin. Nutr.Home page
R. Carmel, R. Green, D. W Jacobsen, K. Rasmussen, M. Florea, and C. Azen
Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities
Am. J. Clinical Nutrition, November 1, 1999; 70(5): 904 - 910.
[Abstract] [Full Text] [PDF]


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Am. J. Clin. Nutr.Home page
S. P Stabler, R. H Allen, L. P Fried, M. Pahor, S. J Kittner, B. W. Penninx, and J. M Guralnik
Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women
Am. J. Clinical Nutrition, November 1, 1999; 70(5): 911 - 919.
[Abstract] [Full Text] [PDF]


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ANN INTERN MEDHome page
J. Selhub, P. F. Jacques, I. H. Rosenberg, G. Rogers, B. A. Bowman, E. W. Gunter, J. D. Wright, and C. L. Johnson
Serum Total Homocysteine Concentrations in the Third National Health and Nutrition Examination Survey (1991-1994): Population Reference Ranges and Contribution of Vitamin Status to High Serum Concentrations
Ann Intern Med, September 7, 1999; 131(5): 331 - 339.
[Abstract] [Full Text] [PDF]


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Arterioscler. Thromb. Vasc. Bio.Home page
A. G. Bostom, L. Bausserman, P. F. Jacques, G. Liaugaudas, J. Selhub, and I. H. Rosenberg
Cystatin C as a Determinant of Fasting Plasma Total Homocysteine Levels in Coronary Artery Disease Patients With Normal Serum Creatinine
Arterioscler Thromb Vasc Biol, September 1, 1999; 19(9): 2241 - 2244.
[Abstract] [Full Text] [PDF]


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CMAJHome page
C. G. van Walraven and C. D. Naylor
Use of vitamin B12 injections among elderly patients by primary care practitioners in Ontario
Can. Med. Assoc. J., July 1, 1999; 161(2): 146 - 149.
[Abstract] [Full Text] [PDF]


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Am. J. Clin. Nutr.Home page
R. Z Stolzenberg-Solomon, E. R Miller III, M. G Maguire, J. Selhub, and L. J Appel
Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population
Am. J. Clinical Nutrition, March 1, 1999; 69(3): 467 - 475.
[Abstract] [Full Text] [PDF]


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Clin. Chem.Home page
G. Holleland, J. Schneede, P. M. Ueland, P. K. Lund, H. Refsum, and S. Sandberg
Cobalamin Deficiency in General Practice. Assessment of the Diagnostic Utility and Cost-Benefit Analysis of Methylmalonic Acid Determination in Relation to Current Diagnostic Strategies
Clin. Chem., February 1, 1999; 45(2): 189 - 198.
[Abstract] [Full Text] [PDF]


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J. Nutr.Home page
J. Andrade Juguan, W. Lukito, and W. Schultink
Thiamine Deficiency is Prevalent in a Selected Group of Urban Indonesian Elderly People
J. Nutr., February 1, 1999; 129(2): 366 - 371.
[Abstract] [Full Text] [PDF]


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BloodHome page
A. M. Kuzminski, E. J. Del Giacco, R. H. Allen, S. P. Stabler, and J. Lindenbaum
Effective Treatment of Cobalamin Deficiency With Oral Cobalamin
Blood, August 15, 1998; 92(4): 1191 - 1198.
[Abstract] [Full Text] [PDF]


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Arch Intern MedHome page
J. H. Stein and P. E. McBride
Hyperhomocysteinemia and Atherosclerotic Vascular Disease: Pathophysiology, Screening, and Treatment
Arch Intern Med, June 22, 1998; 158(12): 1301 - 1306.
[Abstract] [Full Text] [PDF]


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J. Nutr.Home page
K. M. Koehler, S. L. Pareo-Tubbeh, H. C. Liang, L. J. Romero, R. N. Baumgartner, and P. J. Garry
Some Vitamin Sources Relating to Plasma Homocysteine Provide not only Folate but also Vitamins B-12 and B-6
J. Nutr., August 1, 1997; 127(8): 1534 - 1535.
[Full Text]


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JAMAHome page
K. L. Tucker, B. Mahnken, P. W. F. Wilson, P. Jacques, and J. Selhub
Folic Acid Fortification of the Food Supply: Potential Benefits and Risks for the Elderly Population
JAMA, December 18, 1996; 276(23): 1879 - 1885.
[Abstract] [PDF]


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JAMAHome page
M. J. Stampfer and E. B. Rimm
Folate and Cardiovascular Disease: Why We Need a Trial Now
JAMA, June 26, 1996; 275(24): 1929 - 1930.
[Abstract] [PDF]


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JAMAHome page
S. A. A. Beresford, A. G. Motulsky, G. S. Omenn, and C. J. Boushey
Folic Acid Fortification of Food-Reply
JAMA, March 6, 1996; 275(9): 682 - 683.
[Abstract] [PDF]


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JAMAHome page
G. P. Oakley Jr, J. D. Erickson, and M. J. Adams Jr
Urgent Need to Increase Folic Acid Consumption
JAMA, December 6, 1995; 274(21): 1717 - 1718.
[Abstract] [PDF]


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JAMAHome page
C. J. Boushey, S. A. A. Beresford, G. S. Omenn, and A. G. Motulsky
A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease: Probable Benefits of Increasing Folic Acid Intakes
JAMA, October 4, 1995; 274(13): 1049 - 1057.
[Abstract] [PDF]




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