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American Journal of Clinical Nutrition, Vol 60, 430-436, Copyright © 1994 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Interactions between alcohol and beta-carotene in patients with alcoholic liver disease

S Ahmed, MA Leo and CS Lieber
Section of Liver Disease and Nutrition, Bronx VA Medical Center, NY 10468.

We found lower plasma beta-carotene concentrations in alcoholics than in control subjects, but heavy drinkers (> or = 200 g/d) had about twice the beta-carotene of those drinking less (P < 0.01), with a significant correlation between plasma beta-carotene and alcohol intake (r = 0.6, P < 0.001). When beta-carotene beadlets (30-60 mg/d) were administered to hospitalized alcoholics given controlled diets, those with cirrhosis had a much lower plasma beta-carotene response than those without; the latter in turn responded with lower beta-carotene concentrations than did control subjects. Plasma retinol, alpha- tocopherol, and other carotenoids, such as lycopene, did not differ significantly. We concluded that plasma beta-carotene is relatively increased by heavy alcohol consumption, whereas in patients with liver damage, especially cirrhosis, it is lowered. In these patients, beta- carotene supplementation may be justified, but this should be coupled with control of drinking because of possible hepatotoxic alcohol-beta- carotene interactions.


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