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American Journal of Clinical Nutrition, Vol 60, 510-517, Copyright © 1994 by The American Society for Clinical Nutrition, Inc


ORIGINAL RESEARCH COMMUNICATIONS

Selenium status, fatty acids, vitamins A and E, and aging: the Nove Study [published erratum appears in Am J Clin Nutr 1995 May;61(5):1174]

O Olivieri, AM Stanzial, D Girelli, MT Trevisan, P Guarini, M Terzi, S Caffi, F Fontana, M Casaril and S Ferrari
Institute of Medical Pathology, University of Verona, Italy.

To investigate the relationships between aging and selenium status, vitamins A and E, and plasma and erythrocyte fatty acids, we studied 105 healthy subjects (53 women, 52 men) living in Nove, a village near Vicenza (Veneto Region, northern Italy). The subjects were distributed equally for age and sex into four groups: group 1, 20-39 y; group 2, 40- 59 y; group 3, 60-75 y; and group 4, > 75 y. A careful selection of subjects to exclude those with chronic or acute diseases was obtained with the collaboration of the three general practitioners operating in Nove. Aging was associated with a progressive decrease in selenium status and in the ratio of plasma and erythrocyte polyunsaturated to saturated fatty acids (P:S). Stepwise multiple linear analysis revealed age, vitamin A, and n-6 polyunsaturated fatty acids (PUFAs) as useful predictors of a substantial proportion of the selenium variability (R = 0.618, R2 = 0.382; P < 0.001) and age and erythrocyte oleic acid as predictors of erythrocyte glutathione peroxidase variability (R = 0.413, R2 = 0.17; P < 0.001).


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Copyright © 1994 by The American Society for Nutrition