American Journal of Clinical Nutrition, Vol 60, 534-543, Copyright © 1994 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Alterations in fuel selection and voluntary food intake in response to isoenergetic manipulation of glycogen stores in humans

PS Shetty, AM Prentice, GR Goldberg, PR Murgatroyd, AP McKenna, RJ Stubbs and PA Volschenk
MRC Dunn Clinical Nutrition Centre, Cambridge, UK.

This study investigated the relative importance of alterations in carbohydrate intake or oxidation as mechanisms for rectifying extreme perturbations of glycogen stores. Six lean men were studied on three occasions in which a stabilization period (days 1 and 2) was immediately followed by whole-body indirect calorimetry (days 3-5). Glycogen stores were manipulated on days 3 and 4 by using isoenergetic diets providing carbohydrate at 79% (HC), 48% (MC), or 9% (LC) of energy. Free access to MC meals and snacks was allowed on days 5 and 6 outside the calorimeter. The manipulations caused large alterations in glycogen stores (HC, +206 g; MC, +132 g; LC, -121 g; HC vs LC, 327 g), but subsequent voluntary food intake was very similar across treatments (HC, 18.2 MJ/36 h; MC, 17.7 MJ/36 h; LC, 18.1 MJ/36 h, NS). Over days 3- 5 the average difference in carbohydrate intake (HC vs LC) was 16.1 MJ (1010 g), but balances differed by only 1.7 MJ (110 g) because of autoregulatory changes in carbohydrate oxidation. These were the only significant mechanisms for reestablishing carbohydrate balance.

This article has been cited by other articles:

				J. E. Galgani, C. Moro, and E. Ravussin Metabolic flexibility and insulin resistance Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E1009 - E1017. [Abstract] [Full Text] [PDF]

				M. Siervo, G. Fruhbeck, A. Dixon, G. R. Goldberg, W. A. Coward, P. R. Murgatroyd, A. M. Prentice, and S. A. Jebb Efficiency of autoregulatory homeostatic responses to imposed caloric excess in lean men Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E416 - E424. [Abstract] [Full Text] [PDF]

				N. Pannacciulli, A. D Salbe, E. Ortega, C. A Venti, C. Bogardus, and J. Krakoff The 24-h carbohydrate oxidation rate in a human respiratory chamber predicts ad libitum food intake Am. J. Clinical Nutrition, September 1, 2007; 86(3): 625 - 632. [Abstract] [Full Text] [PDF]

				L. G Rasmussen, T. M Larsen, P. K Mortensen, A. Due, and A. Astrup Effect on 24-h energy expenditure of a moderate-fat diet high in monounsaturated fatty acids compared with that of a low-fat, carbohydrate-rich diet: a 6-mo controlled dietary intervention trial Am. J. Clinical Nutrition, April 1, 2007; 85(4): 1014 - 1022. [Abstract] [Full Text] [PDF]

				R. H Eckel, T. L Hernandez, M. L Bell, K. M Weil, T. Y Shepard, G. K Grunwald, T. A Sharp, C. C Francis, and J. O Hill Carbohydrate balance predicts weight and fat gain in adults. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 803 - 808. [Abstract] [Full Text] [PDF]

				W. H. Saris Sugars, energy metabolism, and body weight control Am. J. Clinical Nutrition, October 1, 2003; 78(4): 850S - 857. [Abstract] [Full Text] [PDF]

				A. M Prentice and A. A Paul Fat and energy needs of children in developing countries Am. J. Clinical Nutrition, November 1, 2000; 72 (5): 1253S - 1265S. [Abstract] [Full Text] [PDF]

				R. M McDevitt, S. D Poppitt, P. R Murgatroyd, and A. M Prentice Macronutrient disposal during controlled overfeeding with glucose, fructose, sucrose, or fat in lean and obese women Am. J. Clinical Nutrition, August 1, 2000; 72(2): 369 - 377. [Abstract] [Full Text] [PDF]

				K. J. Melanson, M. S. Westerterp-Plantenga, L. A. Campfield, and W. H. M. Saris Appetite and blood glucose profiles in humans after glycogen-depleting exercise J Appl Physiol, September 1, 1999; 87(3): 947 - 954. [Abstract] [Full Text] [PDF]

				M. I. Friedman, R. B. Harris, H. Ji, I. Ramirez, and M. G. Tordoff Fatty acid oxidation affects food intake by altering hepatic energy status Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1999; 276(4): R1046 - R1053. [Abstract] [Full Text] [PDF]