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American Journal of Clinical Nutrition, Vol 60, 991S-996S, Copyright © 1994 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Effect of long-chain fatty acids on low-density-lipoprotein-cholesterol metabolism

LA Woollett and JM Dietschy
Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas 75235-8887.

The concentration of cholesterol in the low-density-lipoprotein (LDL) fraction of plasma is one of the major risk factors for coronary heart disease. Steady-state concentrations of LDL cholesterol in the plasma are determined primarily by the production rate and the rate of removal of LDL cholesterol from the circulation by receptor-dependent transport. The magnitude of these two processes is affected by the type of fatty acid in the diet. Saturated fatty acids with 14 and 16 carbon atoms suppress receptor-dependent LDL-cholesterol transport into the liver, increase the LDL-cholesterol production rate, and raise the plasma LDL-cholesterol concentration. The 9-cis 18:1 fatty acid restores receptor activity, lowers the production rate, and decreases the plasma LDL-cholesterol concentration. In contrast with these fatty acids, the 18:0 and 9-trans 18:1 fatty acids are biologically inactive and so do not change the circulating LDL-cholesterol concentration.


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J.-Y. Lee and T. P. Carr
Dietary Fatty Acids Regulate Acyl-CoA:Cholesterol Acyltransferase and Cytosolic Cholesteryl Ester Hydrolase in Hamsters
J. Nutr., December 1, 2004; 134(12): 3239 - 3244.
[Abstract] [Full Text] [PDF]


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Copyright © 1994 by The American Society for Nutrition