American Journal of Clinical Nutrition, Vol 61, 141-148, Copyright © 1995 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of apolipoprotein E polymorphism on the serum lipid response to a hypolipidemic diet rich in monounsaturated fatty acids in patients with hypercholesterolemia and combined hyperlipidemia

D Zambon, E Ros, E Casals, C Sanllehy, A Bertomeu and I Campero
Lipid Clinic (Gastroenterology Service), Hospital Clinic i Provincial, University of Barcelona, Spain.

We investigated the effect of variation at the apolipoprotein (apo) E gene locus on the serum lipid response to a hypolipidemic diet rich in monounsaturated fatty acids (MUFA). Lipoprotein changes were assessed in 122 outpatients with type IIa (n = 70) and type IIb (n = 52) hyperlipidemia [80 men and 42 women with apo E phenotypes 3/2 (n = 27), 3/3 (n = 48), and 4/3 (n = 47)] who were switched from their basal diet containing 40% fat (22% MUFA) to an isoenergetic diet containing 31% fat (MUFA content similar to that of the basal diet) for 12 wk. Significant (P < 0.005) reductions of total, LDL, and VLDL cholesterol; triglycerides; and apo B occurred in subjects regardless of WHO phenotype. Triglycerides and VLDL cholesterol decreased more in type IIb than in type IIa subjects: 25% vs 12% and 21% vs 15%, respectively (P = 0.01). HDL cholesterol tended to decrease only in women. The heterogeneity of lipoprotein responses to dietary intervention was unrelated to apo E phenotypes. In these hyperlipidemic subjects, however, diet-induced favorable changes in serum lipoproteins were selectively influenced by WHO phenotype.

This article has been cited by other articles:

				L. F Masson, G. McNeill, and A. Avenell Genetic variation and the lipid response to dietary intervention: a systematic review Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1098 - 1111. [Abstract] [Full Text] [PDF]

				D. Zambon, J. Sabate, S. Munoz, B. Campero, E. Casals, M. Merlos, J. C. Laguna, and E. Ros Substituting Walnuts for Monounsaturated Fat Improves the Serum Lipid Profile of Hypercholesterolemic Men and Women: A Randomized Crossover Trial Ann Intern Med, April 4, 2000; 132(7): 538 - 546. [Abstract] [Full Text] [PDF]

				M. Rantala, T. T Rantala, M. J Savolainen, Y. Friedlander, and Y A. Kesaniemi Apolipoprotein B gene polymorphisms and serum lipids: meta-analysis of the role of genetic variation in responsiveness to diet Am. J. Clinical Nutrition, March 1, 2000; 71(3): 713 - 724. [Abstract] [Full Text] [PDF]

				M. Lefevre, H. N. Ginsberg, P. M. Kris-Etherton, P. J. Elmer, P. W. Stewart, A. Ershow, T. A. Pearson, P. S. Roheim, R. Ramakrishnan, J. Derr, et al. ApoE Genotype Does Not Predict Lipid Response to Changes in Dietary Saturated Fatty Acids in a Heterogeneous Normolipidemic Population Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2914 - 2923. [Abstract] [Full Text]

				A. Tall, C. Welch, D. Applebaum-Bowden, and M. Wassef Interaction of Diet and Genes in Atherogenesis Report of an NHLBI Working Group Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 3326 - 3331. [Abstract] [Full Text]

				D. M. Dreon, H. A. Fernstrom, P. T. Williams, and R. M. Krauss LDL Subclass Patterns and Lipoprotein Response to a Low-Fat, High-Carbohydrate Diet in Women Arterioscler. Thromb. Vasc. Biol., April 1, 1997; 17(4): 707 - 714. [Abstract] [Full Text]