American Journal of Clinical Nutrition, Vol 61, 33-38, Copyright © 1995 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Whole-body protein turnover in elderly men and women: responses to two protein intakes

DL Pannemans, D Halliday and KR Westerterp
Department of Human Biology, University of Limburg, Maastricht, Netherlands.

In this study the effect of protein intake (12% and 21% of total energy intake, diets A and B, respectively) on nitrogen balance and on whole- body protein turnover (PT) was measured in 17 elderly men and 11 elderly women (mean +/- SD: 74 +/- 12 y and 68 +/- 9 y, respectively) with different levels of physical activity. Mean (+/- SD) nitrogen balance (diet A: -0.004 +/- 0.027 g.kg-1.d-1, diet B: 0.011 +/- 0.064 g.kg-1.d-1) did not differ significantly from zero during either diet. PT increased significantly when the protein content of the diet increased from 12% to 21% of total energy (P < 0.0001). There was a positive correlation between protein intake and PT (diet A: synthesis and breakdown, P < 0.01; diet B: synthesis, P < 0.001; breakdown, P < 0.0001). PT rates were significantly higher for men when compared with women, even when corrections were made for differences in body composition (P < 0.05).

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