American Journal of Clinical Nutrition, Vol 61, 754-764, Copyright © 1995 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Accurate energy compensation for intragastric and oral nutrients in lean males

DJ Shide, B Caballero, R Reidelberger and BJ Rolls
Nutrition Department, Pennsylvania State University, University Park 16802.

Lean healthy males received either parenteral or enteral infusions of pure fat or carbohydrate (2092 kJ), or isotonic saline, to determine their influences on food intake and energy regulation in self-selected lunch and dinner meals. In the first study, six males received intravenous infusions for 3.5 h in the morning, followed by lunch 30 min after the infusion ended and dinner 6 h later. No compensation was seen for energy differences in intravenous infusions. In the second study, six males received intragastric infusions for 15 min or 3.5 h. Rapid intragastric infusions of fat or carbohydrate and slow infusions of fat significantly reduced intake at lunch, whereas slow carbohydrate infusions did not. In both studies, subjects reduced intake at lunch 30 min after 2092-kJ yogurt preloads varying in fat and carbohydrate, demonstrating their ability to respond to orally derived energy. These results support the existence of mechanisms in the gastrointestinal tract for the rapid detection of the energy content of ingested nutrients or foods in lean males.

This article has been cited by other articles:

				R. J Stratton, R J. Stubbs, and M. Elia Bolus tube feeding suppresses food intake and circulating ghrelin concentrations in healthy subjects in a short-term placebo-controlled trial Am. J. Clinical Nutrition, July 1, 2008; 88(1): 77 - 83. [Abstract] [Full Text] [PDF]

				J. L Temple, C. M Legierski, A. M Giacomelli, S.-J. Salvy, and L. H Epstein Overweight children find food more reinforcing and consume more energy than do nonoverweight children Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1121 - 1127. [Abstract] [Full Text] [PDF]

				K. L. Feltrin, T. J. Little, J. H. Meyer, M. Horowitz, T. Rades, J. Wishart, and C. Feinle-Bisset Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans J. Physiol., June 1, 2007; 581(2): 767 - 777. [Abstract] [Full Text] [PDF]

				D. Rigaud, B. Verges, N. Colas-Linhart, A. Petiet, M. Moukkaddem, V. Van Wymelbeke, and L. Brondel Hormonal and Psychological Factors Linked to the Increased Thermic Effect of Food in Malnourished Fasting Anorexia Nervosa J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1623 - 1629. [Abstract] [Full Text] [PDF]

				S. L Johnson and L. A Taylor-Holloway Non-Hispanic white and Hispanic elementary school children's self-regulation of energy intake Am. J. Clinical Nutrition, June 1, 2006; 83(6): 1276 - 1282. [Abstract] [Full Text] [PDF]

				K. A. Boyd, D. G. O'Donovan, S. Doran, J. Wishart, I. M. Chapman, M. Horowitz, and C. Feinle High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men Am J Physiol Gastrointest Liver Physiol, February 1, 2003; 284(2): G188 - G196. [Abstract] [Full Text] [PDF]

				C. Feinle, D. Grundy, B. Otto, and M. Fried Relationship between increasing duodenal lipid doses, gastric perception, and plasma hormone levels in humans Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1217 - R1223. [Abstract] [Full Text] [PDF]

				I. M Chapman, E. A Goble, G. A Wittert, and M. Horowitz Effects of small-intestinal fat and carbohydrate infusions on appetite and food intake in obese and nonobese men Am. J. Clinical Nutrition, January 1, 1999; 69(1): 6 - 12. [Abstract] [Full Text] [PDF]

				J. H. Meyer, M. Hlinka, Y. Tabrizi, N. DiMaso, and H. E. Raybould Chemical specificities and intestinal distributions of nutrient-driven satiety Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1293 - R1307. [Abstract] [Full Text] [PDF]

				J. H. Meyer, M. Hlinka, A. Khatibi, H. E. Raybould, and P. Tso Role of small intestine in caloric compensations to oil premeals in rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1320 - R1333. [Abstract] [Full Text] [PDF]

				J. M. Andrews, S. Doran, G. S. Hebbard, G. Rassias, W.-M. Sun, and M. Horowitz Effect of glucose supplementation on appetite and the pyloric motor response to intraduodenal glucose and lipid Am J Physiol Gastrointest Liver Physiol, April 1, 1998; 274(4): G645 - G652. [Abstract] [Full Text] [PDF]