| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 62, 143-148, Copyright © 1995 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
KP West Jr, J Katz, SR Shrestha, SC LeClerq, SK Khatry, EK Pradhan, R Adhikari, LS Wu, RP Pokhrel and A Sommer
Department of International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA.
The effect of supplementing 11,918 infants < 1 mo and 1-5 mo of age with vitamin A (15,000 and 30,000 micrograms retinol equivalents or 50,000 and 100,000 IU, respectively) or a placebo on subsequent 4-mo mortality was assessed in a randomized, double-masked community trial in the rural plains of Nepal. There were 130 deaths (51.6/1000 child-y) in the control group and 150 deaths (57.1/1000 child-y) in the vitamin A group, yielding a relative risk of 1.11 (95% CI: 0.86, 1.42), which is indicative of no overall effect on early infant mortality. There was a tendency for the relative risk of mortality among vitamin A recipients to rise with improved nutritional status. These results suggest that distribution of a large oral dose of vitamin A to infants < 5-6 mo of age may not benefit short-term survival. This is in contrast with the results of trials in which older infants and children in this same population were supplemented.
This article has been cited by other articles:
|
|
 |
|
  C. S. Benn, C. Martins, A. Rodrigues, H. Ravn, A. B. Fisker, D. Christoffersen, and P. Aaby The effect of vitamin A supplementation administered with missing vaccines during national immunization days in Guinea-Bissau Int. J. Epidemiol., September 16, 2008; (2008) dyn195v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Abrams and D. C. Hilmers Postnatal Vitamin A Supplementation in Developing Countries: An Intervention Whose Time Has Come? Pediatrics, July 1, 2008; 122(1): 180 - 181. [Full Text] [PDF]
|
|
|
|
|
|
R. D.W. Klemm, A. B. Labrique, P. Christian, M. Rashid, A. A. Shamim, J. Katz, A. Sommer, and K. P. West Jr Newborn Vitamin A Supplementation Reduced Infant Mortality in Rural Bangladesh Pediatrics, July 1, 2008; 122(1): e242 - e250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M Tielsch Vitamin A supplements in newborns and child survival BMJ, June 21, 2008; 336(7658): 1385 - 1386. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sun, R. L. Surles, and S. A. Tanumihardjo Vitamin A Concentrations in Piglet Extrahepatic Tissues Respond Differently Ten Days after Vitamin A Treatment J. Nutr., June 1, 2008; 138(6): 1101 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Tielsch, L. Rahmathullah, R. D. Thulasiraj, J. Katz, C. Coles, S. Sheeladevi, R. John, and K. Prakash Newborn Vitamin A Dosing Reduces the Case Fatality but Not Incidence of Common Childhood Morbidities in South India J. Nutr., November 1, 2007; 137(11): 2470 - 2474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L Surles, J. P Mills, A. R Valentine, and S. A Tanumihardjo One-time graded doses of vitamin A to weanling piglets enhance hepatic retinol but do not always prevent vitamin A deficiency Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1045 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Idindili, H. Masanja, H. Urassa, W. Bunini, P. van Jaarsveld, J. J Aponte, E. Kahigwa, H. Mshinda, D. Ross, and D. M Schellenberg Randomized controlled safety and efficacy trial of 2 vitamin A supplementation schedules in Tanzanian infants Am. J. Clinical Nutrition, May 1, 2007; 85(5): 1312 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Benn, C. Martins, A. Rodrigues, H. Jensen, I. M. Lisse, and P. Aaby Randomised study of effect of different doses of vitamin A on childhood morbidity and mortality BMJ, December 17, 2005; 331(7530): 1428 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rodriguez, D. H Hamer, J. Rivera, M. Acosta, G. Salgado, M. Gordillo, M. Cabezas, C. Naranjo-Pinto, J. Leguisamo, D. Gomez, et al. Effects of moderate doses of vitamin A as an adjunct to the treatment of pneumonia in underweight and normal-weight children: a randomized, double-blind, placebo-controlled trial Am. J. Clinical Nutrition, November 1, 2005; 82(5): 1090 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Li and C. E. Frangakis Designs in partially controlled studies: messages from a review Statistical Methods in Medical Research, August 1, 2005; 14(4): 417 - 431. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Villamor and W. W. Fawzi Effects of Vitamin A Supplementation on Immune Responses and Correlation with Clinical Outcomes Clin. Microbiol. Rev., July 1, 2005; 18(3): 446 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C Malaba, P. J Iliff, K. J Nathoo, E. Marinda, L. H Moulton, L. S Zijenah, P. Zvandasara, B. J Ward, the ZVITAMBO Study Group, and J. H Humphrey Effect of postpartum maternal or neonatal vitamin A supplementation on infant mortality among infants born to HIV-negative mothers in Zimbabwe Am. J. Clinical Nutrition, February 1, 2005; 81(2): 454 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. A. Bhutta, G. L. Darmstadt, B. S. Hasan, and R. A. Haws Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence Pediatrics, February 1, 2005; 115(2/S1): 519 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Ambrus Sr. and J. L. Ambrus Jr. Nutrition and Infectious Diseases in Developing Countries and Problems of Acquired Immunodeficiency Syndrome Experimental Biology and Medicine, June 1, 2004; 229(6): 464 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Benn, C. Bale, H. Sommerfelt, H. Friis, and P. Aaby Hypothesis: Vitamin A supplementation and childhood mortality: amplification of the non-specific effects of vaccines? Int. J. Epidemiol., October 1, 2003; 32(5): 822 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rahmathullah, J. M Tielsch, R D Thulasiraj, J. Katz, C. Coles, S. Devi, R. John, K. Prakash, A V Sadanand, N Edwin, et al. Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India BMJ, July 31, 2003; 327(7409): 254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bahl, N. Bhandari, M. A. Wahed, G. T. Kumar, M. K. Bhan, and the WHO/CHD Immunization-Linked Vitamin A Group Vitamin A Supplementation of Women Postpartum and of Their Infants at Immunization Alters Breast Milk Retinol and Infant Vitamin A Status J. Nutr., November 1, 2002; 132(11): 3243 - 3248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Craft Innovative Approaches to Vitamin A Assessment J. Nutr., May 1, 2001; 131(5): 1626S - 1630. [Abstract] [Full Text]
|
|
|
|
|
|
C. L. Coles, L. Rahmathullah, R. Kanungo, R. D. Thulasiraj, J. Katz, M. Santhosham, and J. M. Tielsch Vitamin A Supplementation at Birth Delays Pneumococcal Colonization in South Indian Infants J. Nutr., February 1, 2001; 131(2): 255 - 261. [Abstract] [Full Text]
|
|
|
|
|
|
J. Katz, K. P West Jr, S. K Khatry, E. K Pradhan, S. C LeClerq, P. Christian, L. S.-F. Wu, R. K Adhikari, S. R Shrestha, and A. Sommer Maternal low-dose vitamin A or {beta}-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1570 - 1576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R J Hayes, N D. Alexander, S Bennett, and S N Cousens Design and analysis issues in cluster-randomized trials of interventions against infectious diseases Statistical Methods in Medical Research, April 1, 2000; 9(2): 95 - 116. [Abstract] [PDF]
|
|
|
|
|
|
F. Sempértegui, B. Estrella, V. Camaniero, V. Betancourt, R. Izurieta, W. Ortiz, E. Fiallo, S. Troya, A. Rodríguez, and J. K. Griffiths The Beneficial Effects of Weekly Low-dose Vitamin A Supplementation on Acute Lower Respiratory Infections and Diarrhea in Ecuadorian Children Pediatrics, July 1, 1999; 104(1): 1e - 1. [Abstract] [Full Text]
|
|
|
|
|
|
S. M Filteau, A. L Rice, J. J Ball, J Chakraborty, R. Stoltzfus, A. de Francisco, and J. F Willumsen Breast milk immune factors in Bangladeshi women supplemented postpartum with retinol or {beta}-carotene Am. J. Clinical Nutrition, May 1, 1999; 69(5): 953 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. West Jr., S. C. LeClerq, S. R. Shrestha, L. S.-F. Wu,, E. K. Pradhan, S. K. Khatry, J. Katz, R. Adhikari, and A. Sommer Effects of Vitamin A on Growth of Vitamin A-Deficient Children: Field Studies in Nepal J. Nutr., October 1, 1997; 127(10): 1957 - 1965. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. SOMMER Vitamin A prophylaxis Arch. Dis. Child., September 1, 1997; 77(3): 191 - 194. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
