American Journal of Clinical Nutrition, Vol 62, 1096S-1100S, Copyright © 1995 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Control of energy intake by energy metabolism

MI Friedman
Monell Chemical Senses Center, Philadelphia, PA 19104-3308, USA.

Eating behavior is controlled by signals that are generated in the postabsorptive metabolism of energy-yielding substrates. Recent work indicates that an event common to the metabolism of glucose and fat provides such a signal. Evidence suggests that eating behavior is triggered by a signal that is tied to hepatic ATP concentrations and is carried from the liver to brain via afferents in the vagus nerve. This metabolic control of eating behavior may link mechanisms of energy storage and expenditure to energy intake. Changes in energy intake associated with alterations in energy expenditure can be viewed as a response to a shift in the partitioning of fuels, which affects the oxidative metabolic pathways that generate the signal controlling eating behavior.

This article has been cited by other articles:

				S. B. Roberts and I. Rosenberg Nutrition and Aging: Changes in the Regulation of Energy Metabolism With Aging Physiol Rev, April 1, 2006; 86(2): 651 - 667. [Abstract] [Full Text] [PDF]

				M.-P. Ruffin, T. Adage, F. Kuipers, J. H. Strubbe, A. J. W. Scheurink, and G. van Dijk Feeding and temperature responses to intravenous leptin infusion are differential predictors of obesity in rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2004; 286(4): R756 - R763. [Abstract] [Full Text] [PDF]

				C. T. Peters, Y.-H. Choi, P. L. Brubaker, and G. H. Anderson A Glucagon-Like Peptide-1 Receptor Agonist and an Antagonist Modify Macronutrient Selection by Rats J. Nutr., August 1, 2001; 131(8): 2164 - 2170. [Abstract] [Full Text] [PDF]

				R. Groscolas, F. Decrock, M.-A. Thil, C. Fayolle, C. Boissery, and J.-P. Robin Refeeding signal in fasting-incubating king penguins: changes in behavior and egg temperature Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2104 - R2112. [Abstract] [Full Text] [PDF]

				P. C. Even, V. Rolland, S. Feurte, G. Fromentin, S. Roseau, S. Nicolaidis, and D. Tome Postprandial metabolism and aversive response in rats fed a threonine-devoid diet Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R248 - R254. [Abstract] [Full Text] [PDF]

				J. E. Schneider, R. M. Blum, and G. N. Wade Metabolic control of food intake and estrous cycles in Syrian hamsters. I. Plasma insulin and leptin Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R476 - R485. [Abstract] [Full Text] [PDF]

				G. van Dijk, R. J. Seeley, T. E. Thiele, M. I. Friedman, H. Ji, C. W. Wilkinson, P. Burn, L. A. Campfield, R. Tenenbaum, D. G. Baskin, et al. Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1425 - R1433. [Abstract] [Full Text] [PDF]

				A.-H. MAMOUN, P. SODERSTEN, B. ANDERSTAM, and J. BERGSTROM Evidence of Splanchnic-Brain Signaling in Inhibition of Ingestive Behavior by Middle Molecules J. Am. Soc. Nephrol., February 1, 1999; 10(2): 309 - 314. [Abstract] [Full Text]

				J.-P. Robin, L. Boucontet, P. Chillet, and R. Groscolas Behavioral changes in fasting emperor penguins: evidence for a "refeeding signal" linked to a metabolic shift Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R746 - R753. [Abstract] [Full Text] [PDF]