AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bertram, J. S.
Right arrow Articles by Bortkiewicz, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bertram, J. S.
Right arrow Articles by Bortkiewicz, H.
Agricola
Right arrow Articles by Bertram, J. S.
Right arrow Articles by Bortkiewicz, H.

American Journal of Clinical Nutrition, Vol 62, 1327S-1336S, Copyright © 1995 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Dietary carotenoids inhibit neoplastic transformation and modulate gene expression in mouse and human cells

JS Bertram and H Bortkiewicz
Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA.

Many epidemiologic studies have associated the consumption of diets rich in fruit and green and yellow vegetables with a decreased risk of cancer. Of the many components of such a diet, the content of carotenoids, particularly beta-carotene, has been most consistently linked to decreased risk. The biological mechanism for such protection is currently unclear. Multiple possibilities exist: carotenoids are potent antioxidants and oxidative stress is known to contribute to carcinogenesis; many carotenoids can be converted to retinoids, these are known cancer preventive agents at several anatomic sites; and carotenoids may possess additional actions in mammalian cells. In a model in vitro system we showed that carotenoids both with and without provitamin A activity inhibit carcinogen-induced neoplastic transformation, inhibit plasma membrane lipid oxidation, and cause up- regulated expression of connexin 43, a gene coding for the structural unit of a gap junction. This last activity was statistically correlated with the ability to inhibit neoplastic transformation. Activity has also been shown in human cells: in fibroblasts CONNEXIN 43 expression is also up-regulated whereas in human keratinocytes grown in organotypic culture beta-carotene and canthaxanthin modulate differentiation in a manner qualitatively similar to that of retinoids. These results strongly suggest that carotenoids have intrinsic cancer chemopreventive action in humans.


This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
F. Granado, B. Olmedilla, C. Herrero, B. Perez-Sacristan, I. Blanco, and S. Blazquez
Bioavailability of Carotenoids and Tocopherols from Broccoli: In Vivo and In Vitro Assessment
Experimental Biology and Medicine, December 1, 2006; 231(11): 1733 - 1738.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
F. Daubrawa, H. Sies, and W. Stahl
Astaxanthin Diminishes Gap Junctional Intercellular Communication in Primary Human Fibroblasts
J. Nutr., November 1, 2005; 135(11): 2507 - 2511.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
L. M. Hix, D. A. Frey, M. D. McLaws, M. Osterlie, S. F. Lockwood, and J. S. Bertram
Inhibition of chemically-induced neoplastic transformation by a novel tetrasodium diphosphate astaxanthin derivative
Carcinogenesis, September 1, 2005; 26(9): 1634 - 1641.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Liu, F. Lian, D. E. Smith, R. M. Russell, and X.-D. Wang
Lycopene Supplementation Inhibits Lung Squamous Metaplasia and Induces Apoptosis via Up-Regulating Insulin-like Growth Factor-binding Protein 3 in Cigarette Smoke-exposed Ferrets
Cancer Res., June 15, 2003; 63(12): 3138 - 3144.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
E. C. Tibaduiza, J. C. Fleet, R. M. Russell, and N. I. Krinsky
Excentric Cleavage Products of {beta}-Carotene Inhibit Estrogen Receptor Positive and Negative Breast Tumor Cell Growth In Vitro and Inhibit Activator Protein-1-Mediated Transcriptional Activation
J. Nutr., June 1, 2002; 132(6): 1368 - 1375.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
T. Narisawa, Y. Fukaura, M. Hasebe, S. Nomura, S. Oshima, and T. Inakuma
Prevention of N-Methylnitrosourea-Induced Colon Carcinogenesis in Rats by Oxygenated Carotenoid Capsanthin and Capsanthin-Rich Paprika Juice
Experimental Biology and Medicine, June 1, 2000; 224(2): 116 - 122.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
T. J. King, L. H. Fukushima, A. D. Hieber, K. A. Shimabukuro, W. A. Sakr, and J. S. Bertram
Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression
Carcinogenesis, June 1, 2000; 21(6): 1097 - 1109.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
S. De Flora, M. Bagnasco, and H. Vainio
Modulation of genotoxic and related effects by carotenoids and vitamin A in experimental models: mechanistic issues
Mutagenesis, March 1, 1999; 14(2): 153 - 172.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. S. Park, B. P. Chew, and T. S. Wong
Dietary Lutein from Marigold Extract Inhibits Mammary Tumor Development in BALB/c Mice
J. Nutr., October 1, 1998; 128(10): 1650 - 1656.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by The American Society for Nutrition