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American Journal of Clinical Nutrition, Vol 62, 1347S-1356S, Copyright © 1995 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Determination of optimal vitamin C requirements in humans

M Levine, KR Dhariwal, RW Welch, Y Wang and JB Park
Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0850, USA.

Although the recommended dietary allowance provides an estimate for vitamin C ingestion in humans, optimal vitamin C requirements are unknown. We define optimal vitamin C requirements operationally based on the following: dose-function relations, availability in the food supply, steady state concentrations in plasma and tissues achieved at each dose of vitamin C, urinary excretion, bioavailability, toxicity, and epidemiologic observations. Optimal vitamin C requirements can be estimated when information is available for at least some of these criteria.


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